|
|
Substance Name: Alfaxalone [INN:BAN:DCF:JAN]
RN: 23930-19-0
UNII: BD07M97B2A
InChIKey: DUHUCHOQIDJXAT-OLVMNOGESA-N
Note
- Constituent of alphadione.
Molecular Formula
- C21-H32-O3
Molecular Weight
- 332.4808
Classification Codes
- Anesthetics
- Central Nervous System Agents
- Central Nervous System Depressants
- Drug / Therapeutic Agent
- Hormone
- Neurosteroids
- Neurotransmitter Agents
* denotes mobile formatted website
Links to Resources
NLM Resources (File Locators)
Other Resources (Internet Locators)
Search for this InChIKey on the Web
Names and Synonyms
Name of Substance
- Alfaxalone [INN:BAN:DCF:JAN]
- Alphaxalone
Synonyms
- (3-alpha,5-alpha)-3-Hydroxypregnane-11,20-dione
- 3-alpha-Hydroxy-5-alpha-pregnane-11,20-dione
- 3-Hydroxypregnane-11,20-dione
- 3alpha-Hydroxy-5alpha-pregnan-11,20-dion
- 3alpha-Hydroxy-5alpha-pregnane-11,20-dione
- 4-08-00-02091 (Beilstein Handbook Reference)
- 5alpha-Pregnan-3alpha-ol-11,20-dione
- Alfaxalona
- Alfaxalona [INN-Spanish]
- Alfaxalone
- Alfaxalonum
- Alfaxalonum [INN-Latin]
- Alphaxalone
- BRN 3217240
- GR 2/234
- UNII-BD07M97B2A
Systematic Names
- 3alpha-Hydroxy-5alpha-pregnane-11,20-dione
- 5-alpha-Pregnane-11,20-dione, 3-alpha-hydroxy-
- Pregnane-11,20-dione, 3-hydroxy-, (3-alpha,5-alpha)-
Registry Numbers
CAS Registry Number
- 23930-19-0
FDA UNII
- BD07M97B2A
System Generated Number
- 0023930190
Structure Descriptors
InChI
InChI=1S/C21H32O3/c1-12(22)16-6-7-17-15-5-4-13-10-14(23)8-9-20(13,2)19(15)18(24)11-21(16,17)3/h13-17,19,23H,4-11H2,1-3H3/t13-,14+,15-,16+,17-,19+,20-,21+/m0/s1InChIKey
DUHUCHOQIDJXAT-OLVMNOGESA-NSmiles
CC(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 430mg/kg (430mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 680, 1977. | |
mouse | LD50 | intravenous | 36900ug/kg (36.9mg/kg) | BEHAVIORAL: GENERAL ANESTHETIC | Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 1, Pg. 119, 1975. |
mouse | LD50 | oral | 880mg/kg (880mg/kg) | Yakkyoku. Pharmacy. Vol. 28, Pg. 1337, 1977. | |
mouse | LD50 | subcutaneous | 5220mg/kg (5220mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 680, 1977. | |
rabbit | LD50 | intravenous | 9360ug/kg (9.36mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 680, 1977. | |
rat | LD50 | intraperitoneal | 116mg/kg (116mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 680, 1977. | |
rat | LD50 | intravenous | 19400ug/kg (19.4mg/kg) | Yakkyoku. Pharmacy. Vol. 28, Pg. 1337, 1977. | |
rat | LD50 | oral | 297mg/kg (297mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 680, 1977. | |
rat | LD50 | subcutaneous | > 2200mg/kg (2200mg/kg) | Yakkyoku. Pharmacy. Vol. 28, Pg. 1337, 1977. |