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Substance Name: Pentamidine [INN:BAN:DCF]
RN: 100-33-4
UNII: 673LC5J4LQ
InChIKey: XDRYMKDFEDOLFX-UHFFFAOYSA-N
Note
- Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
Molecular Formula
- C19-H24-N4-O2
Molecular Weight
- 340.425
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Anti-Infective Agents
- Antifungal Agents
- Antiparasitic Agents
- Antiprotozoal Agents
- Drug / Therapeutic Agent
- Human Data
- Trypanocidal Agents
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Names and Synonyms
Name of Substance
- Pentamidine
- Pentamidine [INN:BAN:DCF]
MeSH Heading
- Pentamidine
Synonyms
- 4,4'-(1,5-Pentanediylbis(oxy))bis-benzenecarboximidamide
- 4,4'-(Pentamethylenedioxy)dibenzamidine
- 4,4'-Diamidinodiphenoxypentane
- 4-10-00-00447 (Beilstein Handbook Reference)
- BRN 3159790
- CCRIS 3825
- EINECS 202-841-0
- HSDB 7474
- MB 800 [as isethionate]
- Nebupent
- Nebupent (as isethionate)
- NSC 9921
- p,p'-(Pentamethylene-dioxy)bis-benzamidine
- p,p'-(Pentamethylenedioxy)dibenzamidine
- Pentacarinat
- Pentacarinat (as isethionate)
- Pentam 300
- Pentam 300 (as isethionate)
- Pentamidina
- Pentamidina [DCIT]
- Pentamidine
- Pentamidinum
- Pentamidinum [INN-Latin]
- RP 2512 [as isethionate]
- UNII-673LC5J4LQ
Systematic Names
- 4,4'-(Pentamethylenedioxy)dibenzamidine
- Benzamidine, 4,4'-(pentamethylenedioxy)di-
- Benzenecarboximidamide, 4,4'-(1,5-pentanediylbis(oxy))bis- (9CI)
- Pentamidine
Registry Numbers
CAS Registry Number
- 100-33-4
FDA UNII
- 673LC5J4LQ
System Generated Number
- 0000100334
Structure Descriptors
InChI
InChI=1S/C19H24N4O2/c20-18(21)14-4-8-16(9-5-14)24-12-2-1-3-13-25-17-10-6-15(7-11-17)19(22)23/h4-11H,1-3,12-13H2,(H3,20,21)(H3,22,23)InChIKey
XDRYMKDFEDOLFX-UHFFFAOYSA-NSmiles
NC(=N)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mammal (species unspecified) | LD50 | subcutaneous | 100mg/kg (100mg/kg) | Bulletin de la Societe Chimique de France. Vol. -, Pg. 376, 1968. | |
man | TDLo | intramuscular | 28mg/kg/1W-I (28mg/kg) | Archives of Internal Medicine. Vol. 145, Pg. 2247, 1985. | |
man | TDLo | intramuscular | 28mg/kg/1W-I (28mg/kg) | KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" | Archives of Internal Medicine. Vol. 145, Pg. 2247, 1985. |
man | TDLo | parenteral | 4mg/kg/3D (4mg/kg) | Lancet. Vol. 246, Pg. 338, 1944. | |
man | TDLo | parenteral | 4mg/kg/3D (4mg/kg) | BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Lancet. Vol. 246, Pg. 338, 1944. |
mouse | LD50 | intraperitoneal | 50mg/kg (50mg/kg) | Journal of Medicinal Chemistry. Vol. 18, Pg. 794, 1975. | |
women | TDLo | parenteral | 4mg/kg (4mg/kg) | ENDOCRINE: HYPOGLYCEMIA | Annals of Internal Medicine. Vol. 99, Pg. 128, 1983. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
log P (octanol-water) | 2.790 | (none) | EST | |
Atmospheric OH Rate Constant | 1.17E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.