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Substance Name: Benzyl alcohol [INN:JAN:NF]
RN: 100-51-6
UNII: LKG8494WBH
InChIKey: WVDDGKGOMKODPV-UHFFFAOYSA-N

Note

  • A colorless liquid with a sharp burning taste and slight odor. It is used as a local anesthetic and to reduce pain associated with LIDOCAINE injection. Also, it is used in the manufacture of other benzyl compounds, as a pharmaceutic aid, and in perfumery and flavoring.

Molecular Formula

  • C7-H8-O

Molecular Weight

  • 108.1392
 

Classification Codes

  • Anesthetics
  • Anesthetics, Local
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Mutation Data
  • Natural Product
  • Peripheral Nervous System Agents
  • Pharmaceutic Aid (Antimicrobial Agent)
  • Reproductive Effect
  • Sensory System Agents
  • Skin / Eye Irritant
  • Tumor Data

Names and Synonyms

Name of Substance

  • Benzenemethanol
  • Benzyl alcohol
  • Benzyl alcohol [INN:JAN:NF]

MeSH Heading

  • Benzyl alcohol

Synonyms

  • (Hydroxymethyl)benzene
  • 4-06-00-02222 (Beilstein Handbook Reference)
  • AI3-01680
  • Alcohol bencilico
  • Alcohol bencilico [INN-Spanish]
  • Alcoholum benzylicum
  • Alcoholum benzylicum [INN-Latin]
  • Alcool benzilico
  • Alcool benzilico [DCIT]
  • Alcool benzylique
  • Alcool benzylique [INN-French]
  • alpha-Toluenol
  • Benzal alcohol
  • Benzenecarbinol
  • Benzenemethanol
  • Benzoyl alcohol
  • Benzyl alcohol
  • Benzyl alcohol (natural)
  • Benzylicum
  • BRN 0878307
  • Caswell No. 081F
  • CCRIS 2081
  • EC 202-859-9
  • EINECS 202-859-9
  • EPA Pesticide Chemical Code 009502
  • Euxyl K 100
  • FEMA No. 2137
  • HSDB 46
  • Hydroxytoluene
  • Methanol, phenyl-
  • NCI-C06111
  • NSC 8044
  • Phenolcarbinol
  • Phenylcarbinol
  • Phenylcarbinolum
  • Phenylmethanol
  • Phenylmethyl alcohol
  • Ulesfia
  • UNII-LKG8494WBH

Systematic Names

  • Benzenemethanol
  • Benzyl alcohol

Superlist Names

  • Benzenemethanol
  • Benzyl alcohol

Mixture Name

  • Itch-X

Registry Numbers

CAS Registry Number

  • 100-51-6

FDA UNII

  • LKG8494WBH

Other Registry Numbers

  • 1336-27-2
  • 185532-71-2

System Generated Number

  • 0000100516

Structure Descriptors

InChI

1S/C7H8O/c8-6-7-4-2-1-3-5-7/h1-5,8H,6H2

InChIKey

WVDDGKGOMKODPV-UHFFFAOYSA-N

Smiles

OCc1ccccc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - wild LD50 oral 100mg/kg (100mg/kg)   Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.
cat LDLo intravenous 625mg/kg (625mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 16, Pg. 1, 1920.
cat LDLo skin 10gm/kg (10000mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: TREMOR
Journal of Pharmacology and Experimental Therapeutics. Vol. 84, Pg. 358, 1945.
dog LDLo intravenous 50mg/kg (50mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Toxicology and Applied Pharmacology. Vol. 18, Pg. 60, 1971.
dog LDLo parenteral 9mg/kg (9mg/kg) BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Toxicology and Applied Pharmacology. Vol. 25, Pg. 153, 1973.
guinea pig LD50 oral 2500mg/kg (2500mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 50(7), Pg. 81, 1985.
mouse LD50 intraperitoneal 650mg/kg (650mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Journal of Pharmaceutical Sciences. Vol. 75, Pg. 702, 1986.
mouse LD50 intravenous 324mg/kg (324mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 135, Pg. 330, 1962.
mouse LD50 oral 1360mg/kg (1360mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 50(7), Pg. 81, 1985.
rabbit LD50 oral 1040mg/kg (1040mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Journal of Pharmacology and Experimental Therapeutics. Vol. 84, Pg. 358, 1945.
rabbit LD50 skin 2gm/kg (2000mg/kg)   Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 6, 1974.
rat LCLo inhalation 1000ppm/8H (1000ppm)   AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 4, Pg. 119, 1951.
rat LD50 intraarterial 441mg/kg (441mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA
Toxicology and Applied Pharmacology. Vol. 18, Pg. 60, 1971.
rat LD50 intraperitoneal 400mg/kg (400mg/kg)   Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 6, 1974.
rat LD50 intravenous 53mg/kg (53mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA Toxicology and Applied Pharmacology. Vol. 18, Pg. 60, 1971.
rat LD50 oral 1230mg/kg (1230mg/kg) BEHAVIORAL: COMA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: EXCITEMENT
Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964.
rat LDLo subcutaneous 1700mg/kg (1700mg/kg) BEHAVIORAL: COMA

KIDNEY, URETER, AND BLADDER: OTHER CHANGES

SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE
Revue Medicale de la Suisse Romande. Vol. 15, Pg. 561, 1895.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point -1.52E+01 deg C   EXP
Boiling Point 205.3 deg C   EXP
pKa Dissociation Constant 15.4 (none)   EXP
log P (octanol-water) 1.1 (none)   EXP
Water Solubility 4.29E+04 mg/L 25 EXP
Vapor Pressure 0.094 mm Hg 25 EXP
Henry's Law Constant 3.37E-07 atm-m3/mole 25 EXP
Atmospheric OH Rate Constant 2.29E-11 cm3/molecule-sec 25 EXP

Physical property data is provided to ChemIDplus by SRC, Inc.