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Substance Name: Mephentermine [INN:BAN]
RN: 100-92-5
UNII: TEZ91L71V4
InChIKey: RXQCGGRTAILOIN-UHFFFAOYSA-N

Note

  • A sympathomimetic agent with specificity for alpha-1 adrenergic receptors. It is used to maintain BLOOD PRESSURE in hypotensive states such as following SPINAL ANESTHESIA.

Molecular Formula

  • C11-H17-N

Molecular Weight

  • 163.2623
 

Classification Codes

  • Adrenergic Agents
  • Adrenergic Agonists
  • Adrenergic alpha-1 Receptor Agonists
  • Adrenergic alpha-Agonists
  • Autonomic Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Neurotransmitter Agents
  • Peripheral Nervous System Agents
  • Sympathomimetics
  • Vasoconstrictor Agents
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Names and Synonyms

Results Name

  • Mephentermine [INN:BAN]

Name of Substance

  • Mephentermine
  • Mephentermine [INN:BAN]

MeSH Heading

  • Mephentermine

Synonyms

  • 2-Methyl-2-methylamino-1-phenylpropane
  • 2-Methylamino-2-methyl-1-phenylpropane
  • 4-12-00-02820 (Beilstein Handbook Reference)
  • Benzeneethanamine, N,alpha,alpha-trimethyl-
  • BRN 1363850
  • EINECS 202-901-6
  • HSDB 2172
  • Mefenterdrin
  • Mefentermin
  • Mefentermina
  • Mefentermina [INN-Spanish]
  • Mephenterdrine
  • Mephenterdrinum
  • Mephentermine
  • Mephenterminum
  • Mephenterminum [INN-Latin]
  • Mephetedrine
  • Mephine
  • N,alpha,alpha-Trimethylbenzeneethanamine
  • N,alpha,alpha-Trimethylphenethylamine
  • N-Methyl-omega-phenyl-t-butylamine
  • N-Methyl-omega-phenyl-tert-butylamine
  • N-Methylphentermine
  • omega-Phenyl-tert-butyl-methylamine
  • Phenethylamine, N,alpha,alpha-trimethyl-
  • UNII-TEZ91L71V4
  • Vialin
  • WY-585
  • Wyamine
  • Wyfentermina

Systematic Names

  • Benzeneethanamine, N,alpha,alpha-trimethyl-
  • Mephentermine
  • Phenethylamine, N,alpha,alpha-trimethyl-

Registry Numbers

CAS Registry Number

  • 100-92-5

FDA UNII

  • TEZ91L71V4

Related Registry Number

  • 1212-72-2 (sulfate (2:1))

System Generated Number

  • 0000100925

Structure Descriptors

InChI

1S/C11H17N/c1-11(2,12-3)9-10-7-5-4-6-8-10/h4-8,12H,9H2,1-3H3

InChIKey

RXQCGGRTAILOIN-UHFFFAOYSA-N

Smiles

CNC(C)(C)Cc1ccccc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 89mg/kg (89mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: TREMOR

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
Zentralblatt fuer Pharmazie, Pharmakotherapie und Laboratoriums-diagnostik. Vol. 111, Pg. 169, 1972.
mouse LD50 intravenous 43mg/kg (43mg/kg) BEHAVIORAL: TREMOR

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: EXCITEMENT
Zentralblatt fuer Pharmazie, Pharmakotherapie und Laboratoriums-diagnostik. Vol. 111, Pg. 169, 1972.
mouse LD50 oral 57mg/kg (57mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: TREMOR

BEHAVIORAL: EXCITEMENT
Zentralblatt fuer Pharmazie, Pharmakotherapie und Laboratoriums-diagnostik. Vol. 111, Pg. 169, 1972.
rat LD50 intraperitoneal 85mg/kg (85mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: TREMOR

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
Zentralblatt fuer Pharmazie, Pharmakotherapie und Laboratoriums-diagnostik. Vol. 111, Pg. 169, 1972.
rat LD50 intravenous 13mg/kg (13mg/kg) BEHAVIORAL: TREMOR

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: EXCITEMENT
Zentralblatt fuer Pharmazie, Pharmakotherapie und Laboratoriums-diagnostik. Vol. 111, Pg. 169, 1972.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point < 25 deg C   EXP
log P (octanol-water) 2.670 (none)   EST
Atmospheric OH Rate Constant 7.06E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.