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Substance Name: Tesevatinib tosylate [USAN]
RN: 1000599-06-3
UNII: GKB6T21I50
InChIKey: GQLLAIBEWDUUBQ-QIYAQLFNSA-N

Note

  • NCI: An orally bioavailable small-molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. Tesevatinib binds to and inhibits several tyrosine receptor kinases that play major roles in tumor cell proliferation and tumor vascularization, including epidermal growth factor receptor (EGFR; ERBB1), epidermal growth factor receptor 2 (HER2; ERBB2), vascular endothelial growth factor receptor (VEGFR), and ephrin B4 (EphB4). This may result in the inhibition of tumor growth and angiogenesis, and tumor regression. (NCI Thesaurus)

Molecular Weight

  • 663.5947
 

Classification Code

  • Treatment of Cancer and Polycystic Kidney Disease
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Names and Synonyms

Name of Substance

  • Tesevatinib tosylate [USAN]
  • Xl-647 tosylate

Synonyms

  • 4-Quinazolinamine, N-(3,4-dichloro-2-fluorophenyl)-6-methoxy-7-(((3aR,6aS)-octahydro-2-methylcyclopenta(c)pyrrol-5-yl)methoxy)-, 4-methylbenzenesulfonate (1:1)
  • 4-Quinazolinamine, N-(3,4-dichloro-2-fluorophenyl)-6-methoxy-7-(((3aR,6aS)-octahydro-2-methylcyclopenta(c)pyrrol-5-yl)methoxy)-, 4-methylbenzenesulphonate (1:1)
  • Tesevatinib tosylate
  • UNII-GKB6T21I50

Registry Numbers

CAS Registry Number

  • 1000599-06-3

FDA UNII

  • GKB6T21I50

System Generated Number

  • 1000599063

Structure Descriptors

InChI

1S/C24H25Cl2FN4O2.C7H8O3S/c1-31-9-14-5-13(6-15(14)10-31)11-33-21-8-19-16(7-20(21)32-2)24(29-12-28-19)30-18-4-3-17(25)22(26)23(18)27;1-6-2-4-7(5-3-6)11(8,9)10/h3-4,7-8,12-15H,5-6,9-11H2,1-2H3,(H,28,29,30);2-5H,1H3,(H,8,9,10)/t13-,14-,15+;

InChIKey

GQLLAIBEWDUUBQ-QIYAQLFNSA-N

Smiles

Cc1ccc(cc1)S(=O)(=O)O.CN1C[C@H]2C[C@H](C[C@H]2C1)COc3cc4c(cc3OC)c(ncn4)Nc5ccc(c(c5F)Cl)Cl