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Substance Name: Ipatasertib [USAN:INN]
RN: 1001264-89-6
UNII: 524Y3IB4HQ
InChIKey: GRZXWCHAXNAUHY-NSISKUIASA-N

Note

  • NCI: Ipatasertib. An orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Ipatasertib binds to and inhibits the activity of Akt in a non-ATP-competitive manner, which may result in the inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents. Check for active clinical trials using this agent. (NCI Thesaurus)

Molecular Formula

  • C24-H32-Cl-N5-O2

Molecular Weight

  • 458.0028
 
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Names and Synonyms

Name of Substance

  • Ipatasertib [USAN:INN]

Synonyms

  • (2S)-2-(4-Chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta(d)pyrimidin-4-yl)piperazin-1-yl(-3-((propan-2-yl)amino)propan-1-one
  • GDC 0068
  • GDC-0068
  • Ipatasertib
  • RG 7440
  • RG7440
  • UNII-524Y3IB4HQ

Systematic Name

  • 1-Propanone, 2-(4-chlorophenyl)-1-(4-((5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl)-1-piperazinyl)-3-((1-methylethyl)amino)-, (2S)-

Registry Numbers

CAS Registry Number

  • 1001264-89-6

FDA UNII

  • 524Y3IB4HQ

Other Registry Number

  • 1417449-25-2

System Generated Number

  • 1001264896

Structure Descriptors

InChI

1S/C24H32ClN5O2/c1-15(2)26-13-19(17-4-6-18(25)7-5-17)24(32)30-10-8-29(9-11-30)23-21-16(3)12-20(31)22(21)27-14-28-23/h4-7,14-16,19-20,26,31H,8-13H2,1-3H3/t16-,19-,20-/m1/s1

InChIKey

GRZXWCHAXNAUHY-NSISKUIASA-N

Smiles

CC(C)NC[C@@H](C(=O)N1CCN(CC1)c2ncnc3[C@H](O)C[C@@H](C)c23)c4ccc(Cl)cc4