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Substance Name: Sodium Picosulfate [INN:BAN:JAN]
RN: 10040-45-6
UNII: VW106606Y8
InChIKey: GOZDTZWAMGHLDY-UHFFFAOYSA-L

Note

  • Contains: sodium picosulfate; used for colon cleansing before colonoscopy.

Molecular Formulas

  • C18-H13-N-Na2-O8-S2
  • C18-H13-N-O8-S2.2Na
  • C18-H15-N-O8-S2.2Na

Molecular Weight

  • 481.4117
 

Classification Codes

  • Cathartics
  • Drug / Therapeutic Agent
  • Gastrointestinal Agents
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Picosulfate sodium
  • Sodium Picosulfate [INN:BAN:JAN]

Synonyms

  • 2-Picolylidenebis(p-phenyl sodium sulfate)
  • 4,4'-(2-Picolylidene)bis(phenylsulfuric acid) disodium salt
  • 4,4'-(2-Pyridinylmethylene)bisphenol bis(hydrogen sulfate) (ester) disodium salt
  • 4,4'-(2-Pyridylmethylene)diphenolbis(hydrogen sulfate) (ester) disodium salt
  • DA 1773
  • DA-1773
  • Disodium 4,4'-disulfoxydiphenyl-(2-pyridyl)methane
  • EINECS 233-120-9
  • Evacuol
  • Evanol
  • Guttalax
  • Guttalax-Fher
  • LA 391
  • Laxidogol
  • Laxoberal
  • Laxoberon
  • Natrii picosulfas
  • Natrii picosulfas [INN-Latin]
  • Neopax
  • Pico-Salax
  • Picolax
  • Picoprep
  • Picosulfate de sodium
  • Picosulfate de sodium [INN-French]
  • Picosulfate sodium
  • Picosulfato sodico
  • Picosulfato sodico [INN-Spanish]
  • Picosulfol
  • Rapilax
  • Sodium picosulfate
  • Sodium picosulphate
  • UNII-VW106606Y8

Systematic Names

  • 4,4'-(2-Pyridylmethylene)diphenol bis(hydrogen sulfate) disodium salt
  • Phenol, 4,4'-(2-pyridylmethylene)bis-, bis(hydrogen sulfate), disodium salt
  • Sodium picosulfate

Registry Numbers

CAS Registry Number

  • 10040-45-6

FDA UNII

  • VW106606Y8

Other Registry Numbers

  • 144857-73-8
  • 27946-28-7

System Generated Number

  • 0010040456

Molecular Formulas

Molecular Formulas

  • C18-H13-N-Na2-O8-S2
  • C18-H13-N-O8-S2.2Na
  • C18-H15-N-O8-S2.2Na

Molecular Formula Fragments

  • C18-H13-N-O8-S2
  • C18-H15-N-O8-S2
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C18H15NO8S2.2Na/c20-28(21,22)26-15-8-4-13(5-9-15)18(17-3-1-2-12-19-17)14-6-10-16(11-7-14)27-29(23,24)25;;/h1-12,18H,(H,20,21,22)(H,23,24,25);;/q;2*+1/p-2

InChIKey

GOZDTZWAMGHLDY-UHFFFAOYSA-L

Smiles

[Na+].[Na+].[O-]S(=O)(=O)Oc1ccc(cc1)C(c2ccc(OS(=O)(=O)[O-])cc2)c3ccccn3

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 2900mg/kg (2900mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 341, 1977.
mouse LD50 intravenous 1600mg/kg (1600mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 341, 1977.
mouse LD50 oral 14500mg/kg (14500mg/kg) BEHAVIORAL: ATAXIA

SKIN AND APPENDAGES (SKIN): HAIR: OTHER

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 341, 1977.
mouse LD50 subcutaneous 6420mg/kg (6420mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Nara Igaku Zasshi. Journal of the Nara Medical Association. Vol. 28, Pg. 258, 1977.
rat LD50 intraperitoneal 3gm/kg (3000mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 341, 1977.
rat LD50 intravenous 1450mg/kg (1450mg/kg) BEHAVIORAL: ATAXIA Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 341, 1977.
rat LD50 oral 11300mg/kg (11300mg/kg)   Drugs in Japan Vol. -, Pg. 993, 1995.
rat LD50 subcutaneous 6980mg/kg (6980mg/kg) BEHAVIORAL: COMA

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Nara Igaku Zasshi. Journal of the Nara Medical Association. Vol. 28, Pg. 258, 1977.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 273 dec deg C   EXP
log P (octanol-water) 0.640 (none)   EST
Atmospheric OH Rate Constant 3.59E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.