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Substance Name: Heme arginate
RN: 100438-92-4
UNII: R1B526117P
InChIKey: BONOMRJXDYBFLR-FCYLROMBSA-N

Note

  • Used for treatment of porphyria; induces heme oxygenase.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • Unspecified

Molecular Weight

  • 792.7142
 
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Names and Synonyms

Name of Substance

  • Heme arginate

Synonyms

  • Heme arginate
  • Heme arginate complex
  • Normosang
  • UNII-R1B526117P

Systematic Names

  • Haem arginate
  • Heme arginate
  • Hemearginat
  • Normosang (9CI)

Registry Numbers

CAS Registry Number

  • 100438-92-4

FDA UNII

  • R1B526117P

System Generated Number

  • 0100438924

Structure Descriptors

InChI

1S/C34H34N4O4.C6H14N4O2.Fe/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;7-4(5(11)12)2-1-3-10-6(8)9;/h7-8,13-16,36-37H,1-2,9-12H2,3-6H3,(H,39,40)(H,41,42);4H,1-3,7H2,(H,11,12)(H4,8,9,10);/q;;+2/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;;/t;4-;/m.0./s1

InChIKey

BONOMRJXDYBFLR-FCYLROMBSA-N

Smiles

[H]/N=C(\N)/NCCC[C@@H](C(=O)O)N.Cc1/c/2c/c3n/c(c\c4c(c(c([nH]4)/cc/5\nc(/cc(/c1CCC(=O)O)\[nH]2)C(=C5C)CCC(=O)O)C=C)C)/C(=C3C)C=C.[Fe+2]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 112mg(HAEM)/k (112mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

GASTROINTESTINAL: OTHER CHANGES
Journal of Pharmacy and Pharmacology. Vol. 39, Pg. 780, 1987.
mouse LD50 intravenous 56300ug(HAEM) (56.3mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

GASTROINTESTINAL: OTHER CHANGES
Journal of Pharmacy and Pharmacology. Vol. 39, Pg. 780, 1987.