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Substance Name: Pyrithioxine hydrochloride [JAN]
RN: 10049-83-9
UNII: CFA914331M
InChIKey: LZNSOAFXPYSLRQ-UHFFFAOYSA-N

Note

  • A neurotropic agent which reduces permeability of blood-brain barrier to phosphate. It has no vitamin B6 activity.

Molecular Formula

  • C16-H20-N2-O4-S2.2Cl-H

Molecular Weight

  • 404.9369
 

Classification Code

  • Drug / Therapeutic Agent
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Names and Synonyms

Name of Substance

  • Pyrithioxine hydrochloride [JAN]

Synonyms

  • 3,3'-Dithiobis(methylene)bis(5-hydroxy-6-methyl-4-pyridinemethanol) dihydrochloride
  • Bonifen
  • Dinerfene
  • EINECS 233-178-5
  • Encephabol
  • Enerbol
  • Life
  • NSC 526973
  • Pyriditol
  • Pyridoxin-5'-disulfid dihydrochlorid hydrat
  • Pyridoxin-5'-disulfid dihydrochlorid hydrat [German]
  • Pyrithioxin hydrochloride
  • Pyrithioxine hydrochloride
  • Pyritinol dihydrochloride
  • Pyritioxine hydrochloride
  • UNII-CFA914331M

Systematic Names

  • 4-Pyridinemethanol, 3,3'-(dithiobis(methylene))bis(5-hydroxy-6-methyl-, dihydrochloride (9CI)
  • 4-Pyridinemethanol, 3,3'-(dithiodimethylene)bis(5-hydroxy-6-methyl-, dihydrochloride (8CI)
  • Pyritinol dihydrochloride

Registry Numbers

CAS Registry Number

  • 10049-83-9

FDA UNII

  • CFA914331M

System Generated Number

  • 0010049839

Molecular Formulas

Molecular Formula

  • C16-H20-N2-O4-S2.2Cl-H

Molecular Formula Fragments

  • C16-H20-N2-O4-S2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C16H20N2O4S2.ClH/c1-9-15(21)13(5-19)11(3-17-9)7-23-24-8-12-4-18-10(2)16(22)14(12)6-20;/h3-4,19-22H,5-8H2,1-2H3;1H

InChIKey

LZNSOAFXPYSLRQ-UHFFFAOYSA-N

Smiles

Cc1c(c(c(cn1)CSSCc2cnc(c(c2CO)O)C)CO)O.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 intravenous 124mg/kg (124mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961.
mouse LD50 intraperitoneal 685mg/kg (685mg/kg)   Agents and Actions, A Swiss Journal of Pharmacology. Vol. 16, Pg. 580, 1985.
mouse LD50 intravenous 221mg/kg (221mg/kg)   Trudy Moskovskogo Obshchestva Ispytatelei Prirody. Transactions of the Moscow Society of Naturalists. Vol. 54, Pg. 156, 1978.
mouse LD50 oral 5786mg/kg (5786mg/kg)   Trudy Moskovskogo Obshchestva Ispytatelei Prirody. Transactions of the Moscow Society of Naturalists. Vol. 54, Pg. 156, 1978.
mouse LD50 subcutaneous 3170mg/kg (3170mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961.
rat LD50 intraperitoneal > 1gm/kg (1000mg/kg)   Drugs in Japan Vol. 6, Pg. 643, 1982.
rat LD50 intravenous 300mg/kg (300mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Arzneimittel-Forschung. Drug Research. Vol. 14, Pg. 26, 1964.
rat LD50 oral 6gm/kg (6000mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961.
rat LD50 subcutaneous 3gm/kg (3000mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT
Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961.