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Substance Name: Cifenline succinate [USAN]
RN: 100678-32-8
UNII: 38G16RWJ37
InChIKey: XFUIOIWYMHEPIE-UHFFFAOYSA-N

Classification Codes

  • Cardiac Depressant (Anti-Arrhythmic)
  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C18-H18-N2.C4-H6-O4

Molecular Weight

  • 380.442
 
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Names and Synonyms

Name of Substance

  • Cifenline succinate [USAN]

Synonyms

  • (+-)-2-(2,2-Diphenylcyclopropyl)-2-imidazoline succinate (1:1)
  • 1H-Imidazole, 2-(2,2-diphenylcyclopropyl)-4,5-dihydro-, (+-)-, butanedioate (1:1)
  • 1H-Imidazole, 4,5-dihydro-2-(2,2-diphenylcyclopropyl)-, succinate
  • 4,5-Dihydro-2-(2,2-diphenylcyclopropyl)-1H-imidazole succinate
  • Cibenzoline succinate (1:1)
  • Cifenline succinate
  • Cipralan
  • Ritmalan
  • Ro 22-7796/001
  • UNII-38G16RWJ37

Systematic Names

  • 1H-Imidazole, 2-(2,2-diphenylcyclopropyl)-4,5-dihydro-, (+-)-, butanedioate (1:1)
  • Butanedioic acid, compd. with 2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1H-imidazole (1:1)

Registry Numbers

CAS Registry Number

  • 100678-32-8

FDA UNII

  • 38G16RWJ37

System Generated Number

  • 0100678328

Molecular Formulas

Molecular Formula

  • C18-H18-N2.C4-H6-O4

Molecular Formula Fragments

  • C18-H18-N2
  • C4-H6-O4
  • COMPONENT

Structure Descriptors

InChI

1S/C18H18N2.C4H6O4/c1-3-7-14(8-4-1)18(15-9-5-2-6-10-15)13-16(18)17-19-11-12-20-17;5-3(6)1-2-4(7)8/h1-10,16H,11-13H2,(H,19,20);1-2H2,(H,5,6)(H,7,8)

InChIKey

XFUIOIWYMHEPIE-UHFFFAOYSA-N

Smiles

C1([C@@H](C1)C=1NCCN1)(c1ccccc1)c1ccccc1.C(CCC(=O)O)(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD oral > 56mg/kg (56mg/kg) BEHAVIORAL: TREMOR

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

GASTROINTESTINAL: NAUSEA OR VOMITING
Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 4519, 1988.
dog LD50 intravenous 33300ug/kg (33.3mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

CARDIAC: CHANGE IN RATE
Kiso to Rinsho. Clinical Report. Vol. 25, Pg. 3385, 1991.
mouse LD50 intraperitoneal 73100ug/kg (73.1mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 4485, 1988.
mouse LD50 oral 180mg/kg (180mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 4485, 1988.
mouse LD50 subcutaneous 83300ug/kg (83.3mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 4485, 1988.
rat LD50 intraperitoneal 83400ug/kg (83.4mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 4485, 1988.
rat LD50 intravenous 44400ug/kg (44.4mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 4485, 1988.
rat LD50 oral 359mg/kg (359mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 4485, 1988.
rat LD50 subcutaneous 156mg/kg (156mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 4485, 1988.