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Substance Name: Enpromate [USAN:INN]
RN: 10087-89-5
UNII: HBS2850E4H
InChIKey: NBEALWAVEGMZQY-UHFFFAOYSA-N

Classification Codes

  • Antineoplastic
  • Drug / Therapeutic Agent
  • Mutation Data
  • Tumor Data

Molecular Formula

  • C22-H23-N-O2

Molecular Weight

  • 333.4287
 
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Names and Synonyms

Name of Substance

  • Acetylenic carbamate
  • Enpromate [USAN:INN]

Synonyms

  • 1,1-Diphenyl-2-propynyl cyclohexanecarbamate
  • 1,1-Diphenyl-2-propynyl cyclohexylcarbamate
  • 1,1-Diphenyl-2-propynyl N-cyclohexylcarbamate
  • 1,1-Diphenyl-2-propynyl-N-cyclohexylcarbamate
  • 1,1-Diphenyl-2-propynylcyclophosphamide
  • 2-Propyn-1-ol, 1,1-diphenyl-, cyclohexanecarbamate
  • 59156
  • BRN 2669373
  • CCRIS 1009
  • Empromato
  • Empromato [INN-Spanish]
  • Enpromate
  • Enpromatum
  • Enpromatum [INN-Latin]
  • Lilly 59156
  • NSC 112682
  • UNII-HBS2850E4H

Systematic Names

  • 1,1-Diphenyl-2-propynyl cyclohexylcarbamate
  • 1,1-Diphenyl-2-propynyl-N-cyclohexylcarbamate
  • Carbamic acid, cyclohexyl-, 1,1-diphenyl-2-propynyl ester
  • Cyclohexanecarbamic acid, 1,1-diphenyl-2-propynyl ester

Registry Numbers

CAS Registry Number

  • 10087-89-5

FDA UNII

  • HBS2850E4H

System Generated Number

  • 0010087895

Structure Descriptors

InChI

1S/C22H23NO2/c1-2-22(18-12-6-3-7-13-18,19-14-8-4-9-15-19)25-21(24)23-20-16-10-5-11-17-20/h1,3-4,6-9,12-15,20H,5,10-11,16-17H2,(H,23,24)

InChIKey

NBEALWAVEGMZQY-UHFFFAOYSA-N

Smiles

C(c1ccccc1)(c1ccccc1)(OC(NC1CCCCC1)=O)C#C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 250mg/kg (250mg/kg)   Gann Monograph. Vol. 2, Pg. 261, 1966.
monkey LD50 oral > 250mg/kg (250mg/kg)   Gann Monograph. Vol. 2, Pg. 261, 1966.
mouse LD50 intraperitoneal 374mg/kg (374mg/kg)   Journal of Medicinal Chemistry. Vol. 11, Pg. 1155, 1968.
mouse LD50 oral 1gm/kg (1000mg/kg)   Gann Monograph. Vol. 2, Pg. 261, 1966.