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Substance Name: Ebrotidine [INN]
RN: 100981-43-9
UNII: TMZ3IBW2OW
InChIKey: ZQHFZHPUZXNPMF-UHFFFAOYSA-N

Note

  • An H2-receptor antagonist and gastric mucosa protector.

Molecular Formula

  • C14-H17-Br-N6-O2-S3

Molecular Weight

  • 477.43
 

Classification Codes

  • Anti-Ulcer Agents
  • Drug / Therapeutic Agent
  • Gastrointestinal Agents
  • Histamine Agents
  • Histamine Antagonists
  • Histamine H2 Antagonists
  • Neurotransmitter Agents
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Ebrotidine
  • Ebrotidine [INN]

Synonyms

  • 4-Bromo-N-(((2-(((-((diaminomethylene)amino)-4-thiazolyl)methyl)thio)ethyl)amino)methylene)benzenesulfonamide
  • CCRIS 8106
  • Ebrotidina
  • Ebrotidina [Spanish]
  • Ebrotidine
  • Ebrotiding
  • Ebrotidinum
  • Ebrotidinum [Latin]
  • FI-3542
  • p-Bromo-N-((E)-((2-(((2-((diaminomethylene)amino)-4-thiazolyl)methyl)thio)ethyl)amino)methylene)benzenesulfonamide
  • UNII-TMZ3IBW2OW

Systematic Names

  • Benzenesulfonamide, N-(((2-(((2-((aminoiminomethyl)amino)-4-thiazolyl)methyl)thio)ethyl)amino)methylene)-4-bromo-, (E)-
  • p-Bromo-N-(((2-(((2-((diaminomethylene)amino)-4-thiazolyl)methyl)thio)ethyl)amino)methylene)benzenesulfonamide

Registry Numbers

CAS Registry Number

  • 100981-43-9

FDA UNII

  • TMZ3IBW2OW

System Generated Number

  • 0100981439

Structure Descriptors

InChI

1S/C14H17BrN6O2S3/c15-10-1-3-12(4-2-10)26(22,23)19-9-18-5-6-24-7-11-8-25-14(20-11)21-13(16)17/h1-4,8-9H,5-7H2,(H,18,19)(H4,16,17,20,21)

InChIKey

ZQHFZHPUZXNPMF-UHFFFAOYSA-N

Smiles

s1cc(nc1NC(N)=N)CSCCN\C=N\S(c1ccc(cc1)Br)(=O)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 366mg/kg (366mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 47, Pg. 490, 1997.
mouse LD50 intravenous 107mg/kg (107mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Arzneimittel-Forschung. Drug Research. Vol. 47, Pg. 490, 1997.
mouse LD50 oral > 2gm/kg (2000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 47, Pg. 490, 1997.
rat LD50 intraperitoneal 316mg/kg (316mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 47, Pg. 490, 1997.
rat LD50 intravenous 100mg/kg (100mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

KIDNEY, URETER, AND BLADDER: HEMATURIA
Arzneimittel-Forschung. Drug Research. Vol. 47, Pg. 490, 1997.
rat LD50 oral > 8gm/kg (8000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 47, Pg. 490, 1997.