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Substance Name: 4,4'-Diphenylmethane diisocyanate
RN: 101-68-8
UNII: B0LO6BBS8C
InChIKey: UPMLOUAZCHDJJD-UHFFFAOYSA-N
Note
- Used as a hardening agent incorporated in polyurethanes.
Molecular Formula
- C15-H10-N2-O2
Molecular Weight
- 250.256
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
Classification Codes
- Human Data
- Mutation Data
- Reproductive Effect
- Skin / Eye Irritant
- Tumor Data
Superlist Classification Codes
- Ceiling 0.02 ppm (0.2 mg/m3)
- Overall Carcinogenic Evaluation: Group 3
- Reportable Quantity (RQ) = 5000 lb
- TWA (0.005 ppm)
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Names and Synonyms
Name of Substance
- 4,4'-Diphenylmethane diisocyanate
Synonyms
- 1,1'-Methylenebis(4-isocyanatobenzene)
- 4,4'-Diisocyanatodiphenylmethane
- 4,4'-Diphenylmethane diisocyanate
- 4,4'-Diphenylmethanediisocyante
- 4,4'-Methylenebis(phenyl isocyanate)
- 4,4'-Methylenedi(phenyl isocyanate)
- 4,4'-Methylenedi-p-phenylene diisocyanate
- 4,4'-Methylenediphenyl diisocyanate
- 4,4'-Methylenediphenyl isocyanate
- 4,4'-Methylenediphenylene isocyanate
- 4-13-00-00396 (Beilstein Handbook Reference)
- 4-4'-Diisocyanate de diphenylmethane
- 4-4'-Diisocyanate de diphenylmethane [French]
- AI3-15256
- Benzene, 1,1'-methylenebis(4-isocyanato-
- Bis(1,4-isocyanatophenyl)methane
- Bis(4-isocyanatophenyl)methane
- Bis(p-isocyanatophenyl)methane
- Bis(para-isocyanatophenyl)methane
- BRN 0797662
- Caradate 30
- CCRIS 2303
- Desmodur 44
- Di-(4-isocyanatophenyl)methane
- Difenil-metan-diisocianato
- Difenil-metan-diisocianato [Italian]
- Difenylmethaan-dissocyanaat
- Difenylmethaan-dissocyanaat [Dutch]
- Diphenyl methane diisocyanate
- Diphenylmethan-4,4'-diisocyanat
- Diphenylmethan-4,4'-diisocyanat [German]
- Diphenylmethane diisocyanate
- Diphenylmethyl diisocyanate
- EC 202-966-0
- EINECS 202-966-0
- HSDB 2630
- Hylene M50
- Isocyanic acid, ester with diphenylmethane
- Isocyanic acid, methylenedi-p-phenylene ester
- Isonate
- Isonate 125 MF
- Isonate 125M
- MDI
- MDR
- Methylbisphenyl isocyanate
- Methylene bisphenyl isocyanate
- Methylene di-p-phenylene isocyanate
- Methylenebis(4-isocyanatobenzene)
- Methylenebis(4-phenyl isocyanate)
- Methylenebis(4-phenylene isocyanate)
- Methylenebis(p-phenyl isocyanate)
- Methylenebis(p-phenylene isocyanate)
- Methylenebis(para-phenyl isocyanate)
- Methylenebis(para-phenylene isocyanate)
- Methylenedi-p-phenylene diisocyanate
- Methylenedi-para-phenylene diisocyanate
- Nacconate 300
- NCI-C50668
- NSC 9596
- p,p'-Diphenylmethane diisocyanate
- p,p'-Methylenebis(phenyl isocyanate)
- para,para'-Diphenylmethane diisocyanate
- para,para'-Methylenebis(phenyl isocyanate)
- Rubinate 44
- UNII-B0LO6BBS8C
Systematic Names
- 1,1'-Methylenebis(4-isocyanatobenzene)
- 4,4'-Methylenediphenyl diisocyanate
- 4,4'-Methylenediphenylene diisocyanate
- Benzene, 1,1'-methylenebis(4-isocyanato-
- Isocyanic acid, methylenedi-p-phenylene ester
Superlist Names
- 4,4'-Diphenylmethane diisocyanate
- 4,4'-Methylenediphenyl diisocyanate
- Benzene, 1,1'-methylenebis(4-isocyanato-
- Diphenylmethane diisocyanate
- Diphenylmethane-4,4'-diisocyanate
- Diphenylmethane-4,4'-diisocyanate [UN2489] [Keep away from food]
- Isocyanic acid, methylenedi-p-phenylene ester
- MDI
- Methylene bisphenyl isocyanate
- Methylene diphenyl diisocyanate
- Methylenebis(phenylisocyanate)
- Methylenebis(phenylisocyanate) [Diisocyanates]
- Methylenediphenyl diisocyanate, 4,4'-
- UN2489
Registry Numbers
CAS Registry Number
- 101-68-8
FDA UNII
- B0LO6BBS8C
Other Registry Numbers
- 1211266-59-9
- 1211316-64-1
- 1220313-65-4
- 1400594-70-8
- 142690-07-1
- 1533423-48-1
- 153986-89-1
- 1588489-56-8
- 201528-77-0
- 2031250-39-0
- 2056146-02-0
- 53633-14-0
- 55157-41-0
- 57460-66-9
- 77090-48-3
- 88001-94-9
- 97568-33-7
System Generated Number
- 0000101688
Structure Descriptors
InChI
1S/C15H10N2O2/c18-10-16-14-5-1-12(2-6-14)9-13-3-7-15(8-4-13)17-11-19/h1-8H,9H2InChIKey
UPMLOUAZCHDJJD-UHFFFAOYSA-NSmiles
c1cc(ccc1Cc2ccc(cc2)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
human | TCLo | inhalation | 130ppb/30M (0.13ppm) | American Industrial Hygiene Association Journal. Vol. 27, Pg. 121, 1966. | |
human | TCLo | inhalation | 130ppb/30M (0.13ppm) | IMMUNOLOGICAL INCLUDING ALLERGIC: INCREASED IMMUNE RESPONSE | American Industrial Hygiene Association Journal. Vol. 27, Pg. 121, 1966. |
mouse | LD50 | oral | 2200mg/kg (2200mg/kg) | "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 63, 1982. | |
rat | LC50 | inhalation | 178mg/m3 (178mg/m3) | American Industrial Hygiene Association Journal. Vol. 43, Pg. 89, 1982. | |
rat | LD50 | oral | 9200mg/kg (9200mg/kg) | National Technical Information Service. Vol. OTS0516728, | |
rat | LD50 | oral | 9200mg/kg (9200mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA | National Technical Information Service. Vol. OTS0516728, |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 38 | deg C | EXP | |
log P (octanol-water) | 5.220 | (none) | EST | |
Water Solubility | 0.829 | mg/L | 25 | EST |
Vapor Pressure | 5.00E-06 | mm Hg | 25 | EXP |
Henry's Law Constant | 8.95E-07 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 1.20E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.