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Substance Name: Sodium selenite
RN: 10102-18-8
UNII: HIW548RQ3W
InChIKey: BVTBRVFYZUCAKH-UHFFFAOYSA-L

Note

  • The disodium salt of selenious acid. It is used therapeutically to supply the trace element selenium and is prepared by the reaction of SELENIUM DIOXIDE with SODIUM HYDROXIDE.

Molecular Formulas

  • H2-O3-Se.2Na
  • O3-Se.2Na

Molecular Weight

  • 172.937
 

Classification Codes

Classification Codes

  • Growth Substances
  • Human Data
  • Micronutrients
  • Mutation Data
  • Reproductive Effect
  • Trace Elements
  • Tumor Data

Superlist Classification Codes

  • Reportable Quantity (RQ) = 100 lb
  • Threshold Planning Quantity (TPQ) = 100/10000 lb
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Names and Synonyms

Name of Substance

  • Sodium selenite

MeSH Heading

  • Sodium selenite

Synonyms

  • CCRIS 1260
  • Disodium selenite
  • Disodium selenium trioxide
  • EC 233-267-9
  • EINECS 233-267-9
  • HSDB 768
  • Natriumselenit
  • Natriumselenit [German]
  • Pleo selene
  • Selenious acid (H2SeO3), disodium salt
  • Selenious acid, disodium salt
  • Selenite sodium
  • Sodium selenite
  • Sodium selenite pentahydrate
  • UNII-HIW548RQ3W

Systematic Names

  • Selenious acid, disodium salt
  • Selenious acid, sodium salt (1:2)
  • Sodium selenite

Superlist Names

  • NA2630
  • Selenious acid, disodium salt
  • Sodium selenite
  • Sodium selenite [NA2630] [Poison]

Registry Numbers

CAS Registry Number

  • 10102-18-8

FDA UNII

  • HIW548RQ3W

Other Registry Numbers

  • 29528-97-0
  • 50647-14-8

Related Registry Numbers

  • 14013-56-0 (hydrochloride salt (2:1)
  • 15498-87-0 (hydrochloride salt)
  • 26970-82-1 (pentahydrate)
  • 7782-82-3 (mono-hydrochloride salt)

System Generated Number

  • 0010102188

Molecular Formulas

Molecular Formulas

  • H2-O3-Se.2Na
  • O3-Se.2Na

Molecular Formula Fragments

  • COMPONENT
  • H2-O3-Se
  • Na
  • O3-Se

Structure Descriptors

InChI

1S/2Na.H2O3Se/c;;1-4(2)3/h;;(H2,1,2,3)/q2*+1;/p-2

InChIKey

BVTBRVFYZUCAKH-UHFFFAOYSA-L

Smiles

[Se](=O)([O-])[O-].[Na+].[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cattle LDLo oral 9900ug/kg (9.9mg/kg)   Journal of the American College of Toxicology. Vol. 5(1), Pg. 45, 1986.
chicken LD50 parenteral 8500ug/kg (8.5mg/kg)   Neuropharmacology. Vol. 25, Pg. 493, 1990.
dog LD50 intravenous 1916ug/kg (1.916mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Proceedings of the South Dakota Academy of Science. Vol. 36, Pg. 173, 1957.
dog LDLo subcutaneous 4mg/kg (4mg/kg)   Environmental Quality and Safety, Supplement. Vol. 1, Pg. 1, 1975.
domestic animals - goat/sheep LD50 intramuscular 1533ug/kg (1.533mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Veterinary and Human Toxicology. Vol. 29, Pg. 233, 1987.
domestic animals - goat/sheep LDLo oral 3300ug/kg (3.3mg/kg)   Journal of the American College of Toxicology. Vol. 5(1), Pg. 45, 1986.
guinea pig LD50 oral 5060ug/kg (5.06mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 35(2), Pg. 14, 1970.
horse/donkey LD50 oral 13mg/kg (13mg/kg) CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
American Journal of Veterinary Research. Vol. 41, Pg. 1925, 1980.
man TDLo oral 24mg/kg (24mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Veterinary and Human Toxicology. Vol. 39, Pg. 304, 1997.
mouse LD50 intracervical 300ug/kg (0.3mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Neurotoxicology. Vol. 2, Pg. 383, 1981.
mouse LD50 intravenous 5mg/kg (5mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

CARDIAC: OTHER CHANGES

PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
Neurotoxicology. Vol. 2, Pg. 383, 1981.
mouse LD50 oral 7080ug/kg (7.08mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 35(2), Pg. 14, 1970.
mouse LD50 subcutaneous 13mg/kg (13mg/kg)   Sangyo Igaku. Japanese Journal of Industrial Health. Vol. 17, Pg. 491, 1975.
pig LDLo intramuscular 2190ug/kg (2.19mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Journal of the American Veterinary Medical Association. Vol. 165, Pg. 543, 1974.
pig LDLo intravenous 6570ug/kg (6.57mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS
American Journal of Veterinary Research. Vol. 34, Pg. 1227, 1973.
pig LDLo oral 13mg/kg (13mg/kg)   Journal of the American College of Toxicology. Vol. 5(1), Pg. 45, 1986.
rabbit LD50 intramuscular 2530ug/kg (2.53mg/kg)   Archiv fuer Experimentelle Veterinaermedizin. Vol. 30, Pg. 627, 1976.
rabbit LD50 oral 2250ug/kg (2.25mg/kg)   Hygiene and Sanitation Vol. 35(1-3), Pg. 176, 1970.
rabbit LDLo intraperitoneal 4mg/kg (4mg/kg)   Environmental Quality and Safety, Supplement. Vol. 1, Pg. 1, 1975.
rabbit LDLo intravenous 1971ug/kg (1.971mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 33, Pg. 270, 1928.
rabbit LDLo parenteral 1971ug/kg (1.971mg/kg)   Clinical Toxicology. Vol. 17, Pg. 171, 1980.
rabbit LDLo subcutaneous 6mg/kg (6mg/kg) ENDOCRINE: HYPOGLYCEMIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Proceedings of the Society for Experimental Biology and Medicine. Vol. 24, Pg. 251, 1926.
rat LD50 intravenous 3mg/kg (3mg/kg)   Environmental Quality and Safety, Supplement. Vol. 1, Pg. 1, 1975.
rat LD50 oral 7mg/kg (7mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Toxicology and Applied Pharmacology. Vol. 20, Pg. 89, 1971.
rat LD50 parenteral 6570ug/kg (6.57mg/kg)   Clinical Toxicology. Vol. 17, Pg. 171, 1980.
rat LDLo intraperitoneal 5476ug/kg (5.476mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Journal of Pharmacology and Experimental Therapeutics. Vol. 58, Pg. 454, 1936.