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Substance Name: Nitric oxide [USAN]
RN: 10102-43-9
UNII: 31C4KY9ESH
InChIKey: MWUXSHHQAYIFBG-UHFFFAOYSA-N
Note
- A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
Molecular Formula
- N-O
Molecular Weight
- 30.0061
Classification Codes
Classification Codes
- Anti-Asthmatic Agents
- Antioxidants
- Antiviral (COVID-19)
- Autonomic Agents
- Bronchodilator Agents
- Cardiovascular Agents
- Endogenous Vasodilator used in the Treatment of Hypoxic Respiratory Failure in the Term and Near-Term Neonate
- Endothelium-Dependent Relaxing Factors
- Free Radical Scavengers
- Gasotransmitters
- Mutation Data
- Neurotransmitter Agents
- Peripheral Nervous System Agents
- Respiratory System Agents
- Vasodilator Agents
Superlist Classification Codes
- Reportable Quantity (RQ) = 10 lb
- Threshold Planning Quantity (TPQ) = 100 lb
- TWA (25 ppm); BEI
- TWA 25 ppm (30 mg/m3)
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Names and Synonyms
Name of Substance
- Nitric oxide
- Nitric oxide [USAN]
MeSH Heading
- Nitric oxide
Synonyms
- Amidogen, oxo-
- Bioxyde d'azote
- Bioxyde d'azote [French]
- CCRIS 4319
- EINECS 233-271-0
- HSDB 1246
- INOmax
- Mononitrogen monoxide
- Nitric oxide
- Nitrogen monoxide
- Nitrogen oxide (NO)
- OHM-11771
- Oxyde nitrique
- Oxyde nitrique [French]
- RCRA waste number P076
- Stickmonoxyd
- Stickmonoxyd [German]
- UN 1660
- UNII-31C4KY9ESH
Systematic Names
- Nitric oxide
- Nitrogen monoxide
- Nitrogen oxide (NO)
Superlist Names
- Nitric oxide
- Nitric oxide 10% by volume or more
- Nitric oxide, compressed
- Nitric oxide, compressed [UN1660] [Poison gas]
- Nitrogen oxide
- Nitrogen oxide (NO)
- RCRA waste no. P076
- UN1660
Registry Numbers
CAS Registry Number
- 10102-43-9
FDA UNII
- 31C4KY9ESH
Other Registry Numbers
- 51005-20-0
- 51005-21-1
- 53851-19-7
- 90452-29-2
- 90880-94-7
System Generated Number
- 0010102439
Structure Descriptors
InChI
1S/NO/c1-2InChIKey
MWUXSHHQAYIFBG-UHFFFAOYSA-NSmiles
O=[N]Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LCLo | inhalation | 5000ppm/25M (5000ppm) | LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN | British Journal of Anesthesia. Vol. 39, Pg. 393, 1967. |
mouse | LCLo | inhalation | 320ppm (320ppm) | BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 181, Pg. 145, 1936. |
rat | LC50 | inhalation | 1068mg/m3/4H (1068mg/m3) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 19(4), Pg. 52, 1975. |