|
|
Substance Name: Milnacipran hydrochloride [USAN]
RN: 101152-94-7
UNII: RNZ43O5WW5
InChIKey: XNCDYJFPRPDERF-PBCQUBLHSA-N
Note
- Drugs@FDA Label: Savella /Milnacipran hydrochoride/ is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) indicated for the management of fibromyalgia ...
Molecular Formula
- C15-H22-N2-O.Cl-H
Molecular Weight
- 282.8127
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Formulas
- Structure Descriptors
- Toxicity
Classification Codes
- Drug / Therapeutic Agent
- Reproductive Effect
- Treatment of Fibromyalgia
* denotes mobile formatted website
Links to Resources
NLM Resources (File Locators)
Other Resources (Internet Locators)
Search for this InChIKey on the Web
Names and Synonyms
Results Name
- Milnacipran hydrochloride [USAN]
Name of Substance
- Milnacipran
- Milnacipran hydrochloride
- Milnacipran hydrochloride [USAN]
Synonyms
- (1RS,2SR)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride
- 1-Phenyl-1-(diethylaminocarbonyl)-2-(aminomethyl)cyclopropane hydrochloride
- cis-(+-)-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide monohydrochloride
- Dalcipran
- F 2207
- Ixel
- Milnacipran HCl
- Milnacipran hydrochloride
- NSC 759806
- Savella
- Toledomin
- UNII-RNZ43O5WW5
- Z-2 Aminomethyl-1-phenyl-N,N-diethylcyclopropane-carboxamide hydrochloride
Systematic Names
- Cyclopropanecarboxamide, 2-(aminomethyl)-N,N-diethyl-1-phenyl-, monohydrochloride, (1R,2S)-rel-
- Cyclopropanecarboxamide, 2-(aminomethyl)-N,N-diethyl-1-phenyl-, monohydrochloride, cis-(+-)-
Registry Numbers
CAS Registry Number
- 101152-94-7
FDA UNII
- RNZ43O5WW5
Other Registry Number
- 86181-08-0
System Generated Number
- 0101152947
Molecular Formulas
Molecular Formula
- C15-H22-N2-O.Cl-H
Molecular Formula Fragments
- C15-H22-N2-O
- Cl-H
- COMPONENT
Structure Descriptors
InChI
InChI=1S/C15H22N2O.ClH/c1-3-17(4-2)14(18)15(10-13(15)11-16)12-8-6-5-7-9-12;/h5-9,13H,3-4,10-11,16H2,1-2H3;1H/t13-,15+;/m1./s1InChIKey
XNCDYJFPRPDERF-PBCQUBLHSA-NSmiles
Cl.CCN(CC)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
monkey | LDLo | oral | 500mg/kg (500mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE GASTROINTESTINAL: NAUSEA OR VOMITING | Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 3089, 1994. |
mouse | LD50 | oral | 237mg/kg (237mg/kg) | Journal of Medicinal Chemistry. Vol. 30, Pg. 318, 1987. | |
rat | LD50 | intravenous | 47100ug/kg (47.1mg/kg) | SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 3089, 1994. |
rat | LD50 | oral | 213mg/kg (213mg/kg) | SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 3089, 1994. |
women | TDLo | oral | 120mg/kg/60D- (120mg/kg) | VASCULAR: OTHER CHANGES | Annals of Pharmacotherpy. Vol. 33, Pg. 1009, 1999. |