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Substance Name: Milnacipran hydrochloride [USAN]
RN: 101152-94-7
UNII: RNZ43O5WW5
InChIKey: XNCDYJFPRPDERF-PBCQUBLHSA-N

Note

  • Drugs@FDA Label: Savella /Milnacipran hydrochoride/ is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) indicated for the management of fibromyalgia ...

Molecular Formula

  • C15-H22-N2-O.Cl-H

Molecular Weight

  • 282.8127
 

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect
  • Treatment of Fibromyalgia
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Names and Synonyms

Results Name

  • Milnacipran hydrochloride [USAN]

Name of Substance

  • Milnacipran
  • Milnacipran hydrochloride
  • Milnacipran hydrochloride [USAN]

Synonyms

  • (1RS,2SR)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride
  • 1-Phenyl-1-(diethylaminocarbonyl)-2-(aminomethyl)cyclopropane hydrochloride
  • cis-(+-)-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide monohydrochloride
  • Dalcipran
  • F 2207
  • Ixel
  • Milnacipran HCl
  • Milnacipran hydrochloride
  • NSC 759806
  • Savella
  • Toledomin
  • UNII-RNZ43O5WW5
  • Z-2 Aminomethyl-1-phenyl-N,N-diethylcyclopropane-carboxamide hydrochloride

Systematic Names

  • Cyclopropanecarboxamide, 2-(aminomethyl)-N,N-diethyl-1-phenyl-, monohydrochloride, (1R,2S)-rel-
  • Cyclopropanecarboxamide, 2-(aminomethyl)-N,N-diethyl-1-phenyl-, monohydrochloride, cis-(+-)-

Registry Numbers

CAS Registry Number

  • 101152-94-7

FDA UNII

  • RNZ43O5WW5

Other Registry Number

  • 86181-08-0

System Generated Number

  • 0101152947

Molecular Formulas

Molecular Formula

  • C15-H22-N2-O.Cl-H

Molecular Formula Fragments

  • C15-H22-N2-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

InChI=1S/C15H22N2O.ClH/c1-3-17(4-2)14(18)15(10-13(15)11-16)12-8-6-5-7-9-12;/h5-9,13H,3-4,10-11,16H2,1-2H3;1H/t13-,15+;/m1./s1

InChIKey

XNCDYJFPRPDERF-PBCQUBLHSA-N

Smiles

Cl.CCN(CC)C(=O)[C@@]1(C[C@@H]1CN)c2ccccc2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
monkey LDLo oral 500mg/kg (500mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

GASTROINTESTINAL: NAUSEA OR VOMITING		 Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 3089, 1994.
mouse LD50 oral 237mg/kg (237mg/kg)   Journal of Medicinal Chemistry. Vol. 30, Pg. 318, 1987.
rat LD50 intravenous 47100ug/kg (47.1mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 3089, 1994.
rat LD50 oral 213mg/kg (213mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 3089, 1994.
women TDLo oral 120mg/kg/60D- (120mg/kg) VASCULAR: OTHER CHANGES Annals of Pharmacotherpy. Vol. 33, Pg. 1009, 1999.