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Substance Name: ME 1221
RN: 101233-99-2
InChIKey: KAYODKQGOPMBKS-WEQDFQRJSA-N

Note

  • Exhibits broad antibacterial activity against both Gram-positive and Gram-negative bacteria.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C24-H24-N6-O7-S3

Molecular Weight

  • 604.687
 
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Names and Synonyms

Name of Substance

  • ME 1221

Synonym

  • MT 520

Systematic Names

  • 5H-1-Pyrindinium, 4-(((7-(((2-amino-4-thiazolyl)((carboxymethoxy)imino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)thio)-6,7-dihydro-1-methyl-, hydroxide, inner salt, (6R-(6alpha,7beta(Z)))-
  • 5H-1-Pyrindinium, 6,7-dihydro-4-(((7-(((2-amino-4-thiazolyl)((carboxymethoxy)imino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)thio)-1-methyl-, hydroxide, inner salt, (6R-(6-alpha,7-beta(Z)))-

Registry Numbers

CAS Registry Number

  • 101233-99-2

System Generated Number

  • 0101233992

Structure Descriptors

InChI

1S/C24H24N6O7S3/c1-29-6-5-15(12-3-2-4-14(12)29)38-8-11-9-39-22-18(21(34)30(22)19(11)23(35)36)27-20(33)17(28-37-7-16(31)32)13-10-40-24(25)26-13/h5-6,10,18,22H,2-4,7-9H2,1H3,(H4-,25,26,27,31,32,33,35,36)/b28-17+/t18-,22-/m1/s1

InChIKey

KAYODKQGOPMBKS-WEQDFQRJSA-N

Smiles

C1(=O)[C@H](NC(=O)C(\c2csc(n2)N)=N/OCC(=O)O)[C@H]2SCC(=C(N12)C(=O)[O-])CSc1c2c([n+](cc1)C)CCC2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous > 3gm/kg (3000mg/kg)   Journal of Antibiotics. Vol. 43, Pg. 1150, 1990.