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Substance Name: Eptastigmine [INN]
RN: 101246-68-8
UNII: 6PZZ52D76Q
InChIKey: RRGMXBQMCUKRLH-CTNGQTDRSA-N

Note

  • Possible use in therapy of Alzheimer's disease.

Molecular Formula

  • C21-H33-N3-O2

Molecular Weight

  • 359.511
 

Classification Codes

  • Cholinergic Agents
  • Cholinesterase Inhibitors
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Neurotransmitter Agents
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Names and Synonyms

Name of Substance

  • Eptastigmine
  • Eptastigmine [INN]
  • Physostigmine heptyl

Synonyms

  • (-)-Heptylphysostigmine
  • BRN 4883778
  • Eptastigmina
  • Eptastigmina [INN-Spanish]
  • Eptastigmine
  • Eptastigminum
  • Eptastigminum [INN-Latin]
  • UNII-6PZZ52D76Q

Systematic Names

  • Carbamic acid, heptyl-, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo(2,3-b)indol-5-yl ester, (3aS-cis)-
  • N-Demethyl-N-heptylphysostigmine

Registry Numbers

CAS Registry Number

  • 101246-68-8

FDA UNII

  • 6PZZ52D76Q

System Generated Number

  • 0101246688

Structure Descriptors

InChI

1S/C21H33N3O2/c1-5-6-7-8-9-13-22-20(25)26-16-10-11-18-17(15-16)21(2)12-14-23(3)19(21)24(18)4/h10-11,15,19H,5-9,12-14H2,1-4H3,(H,22,25)/t19-,21+/m1/s1

InChIKey

RRGMXBQMCUKRLH-CTNGQTDRSA-N

Smiles

c12[C@@]3([C@@H](N(c2ccc(OC(=O)NCCCCCCC)c1)C)[N@@](CC3)C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 24mg/kg (24mg/kg)   Journal of Medicinal Chemistry. Vol. 37, Pg. 1996, 1994.
mouse LD50 parenteral 35mg/kg (35mg/kg)   United States Patent Document. Vol. #5306825,