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Substance Name: Sodium tenuazonate
RN: 1013-59-8
UNII: J830SJ75M3
InChIKey: GNZBHOOZDKNFTO-XMLTWROESA-M

Note

  • A metabolite found in a strain of the fungus Alternaria tenuis Auct. which functions as an antibiotic with antiviral and antineoplastic properties, and may also act as a mycotoxin.

Molecular Formulas

  • C10-H14-N-O3.Na
  • C10-H15-N-O3.Na

Molecular Weight

  • 219.215
 

Classification Code

  • Drug / Therapeutic Agent
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Names and Synonyms

Name of Substance

  • Sodium tenuazonate

Synonyms

  • 3-Acetyl-1,5-dihydro-4-hydroxy-5-(1-methylpropyl)-2H-pyrrol-2-one sodium salt
  • 3-Acetyl-5-sec-butyl-4-hydroxy-3-pyrolin-2-one, monosodium salt
  • 3-Acetyl-5-sec-butyl-4-hydroxy-3-pyrrolin-2-one monosodium salt
  • 3-Acetyl-5-sec-butyl-4-hydroxy-3-pyrrolin-2-one sodium salt
  • 3-Acetyltetramic acid sodium salt
  • NSC-525816
  • SK 25816
  • Sodium tenuazonate
  • Tenuazonic acid, sodium salt
  • UNII-J830SJ75M3

Systematic Names

  • 2H-Pyrrol-2-one, 3-acetyl-1,5-dihydro-4-hydroxy-5-(1-methylpropyl)-, monosodium salt, (S-(R*,R*))- (9CI)
  • 3-Pyrrolin-2-one, 3-acetyl-5-sec-butyl-4-hydroxy-, monosodium salt

Registry Numbers

CAS Registry Number

  • 1013-59-8

FDA UNII

  • J830SJ75M3

System Generated Number

  • 0001013598

Molecular Formulas

Molecular Formulas

  • C10-H14-N-O3.Na
  • C10-H15-N-O3.Na

Molecular Formula Fragments

  • C10-H14-N-O3
  • C10-H15-N-O3
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C10H15NO3.Na/c1-4-5(2)8-9(13)7(6(3)12)10(14)11-8;/h5,8,13H,4H2,1-3H3,(H,11,14);/q;+1/p-1/t5-,8-;/m0./s1

InChIKey

GNZBHOOZDKNFTO-XMLTWROESA-M

Smiles

C=1(C(N[C@H](C1[O-])[C@H](CC)C)=O)C(=O)C.[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD intravenous > 40mg/kg (40mg/kg)   Cancer Chemotherapy Reports. Vol. 52, Pg. 579, 1968.
mouse LD50 intravenous 115mg/kg (115mg/kg) BLOOD: HEMORRHAGE

GASTROINTESTINAL: OTHER CHANGES

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Cancer Chemotherapy Reports. Vol. 52, Pg. 579, 1968.
mouse LD50 oral 81mg/kg (81mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BLOOD: HEMORRHAGE

GASTROINTESTINAL: OTHER CHANGES
Cancer Chemotherapy Reports. Vol. 52, Pg. 579, 1968.
rat LD50 intravenous 146mg/kg (146mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BLOOD: HEMORRHAGE

GASTROINTESTINAL: OTHER CHANGES
Cancer Chemotherapy Reports. Vol. 52, Pg. 579, 1968.
rat LD50 oral 168mg/kg (168mg/kg) GASTROINTESTINAL: OTHER CHANGES

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BLOOD: HEMORRHAGE
Cancer Chemotherapy Reports. Vol. 52, Pg. 579, 1968.