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Substance Name: Deptropine methobromide
RN: 10139-98-7
InChIKey: QGWFPTKLAJPIMN-QYESKELBSA-M

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C24-H30-N-O.Br

Molecular Weight

  • 428.411
 
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Names and Synonyms

Name of Substance

  • Deptropine methobromide

Synonyms

  • 3-alpha-((10,11-Dihydro-5H-dibenzo(a,d)cyclohepten-5-yl)oxy)-8-methyltropanium bromide
  • BS 7020a
  • Deptropine methobromide

Systematic Names

  • 1-alpha-H,5-alpha-H-Tropanium, 3-alpha-((10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-yl)oxy)-8-methyl-, bromide
  • endo-3-((10,11-Dihydro-5H-dibenzo(a,d)cyclohepten-5-yl)oxy)-8,8-dimethyl-8-azoniabicyclo(3.2.1)octane, bromide

Registry Numbers

CAS Registry Number

  • 10139-98-7

System Generated Number

  • 0010139987

Molecular Formulas

Molecular Formula

  • C24-H30-N-O.Br

Molecular Formula Fragments

  • Br
  • C24-H30-N-O
  • COMPONENT

Structure Descriptors

InChI

1S/C24H30NO.BrH/c1-25(2)19-13-14-20(25)16-21(15-19)26-24-22-9-5-3-7-17(22)11-12-18-8-4-6-10-23(18)24;/h3-10,19-21,24H,11-16H2,1-2H3;1H/q+1;/p-1/t19-,20+,21+;

InChIKey

QGWFPTKLAJPIMN-QYESKELBSA-M

Smiles

C[N+]1([C@@H]2CC[C@H]1C[C@H](C2)OC3c4ccccc4CCc5c3cccc5)C.[Br-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 71mg/kg (71mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: AGGRESSION
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 192, Pg. 105, 1971.
mouse LD50 intravenous 1150ug/kg (1.15mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 192, Pg. 105, 1971.
mouse LD50 oral 680mg/kg (680mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 192, Pg. 105, 1971.
rabbit LD50 oral 391mg/kg (391mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 192, Pg. 105, 1971.
rat LD50 intraperitoneal 7600ug/kg (7.6mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 192, Pg. 105, 1971.
rat LD50 intravenous 1200ug/kg (1.2mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 192, Pg. 105, 1971.
rat LD50 oral 800mg/kg (800mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 192, Pg. 105, 1971.