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Substance Name: Lomerizine dihydrochloride
RN: 101477-54-7
UNII: 3W473D5LIY
InChIKey: LOGVKVSFYBBUAJ-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C27-H30-F2-N2-O3.2Cl-H

Molecular Weight

  • 541.463
 
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Names and Synonyms

Results Name

  • Lomerizine dihydrochloride

Name of Substance

  • KB 2796
  • Lomerizine dihydrochloride

Synonyms

  • 1-(2,3,4-Trimethoxybenzyl)-4-(bis(4-fluorophenyl)methyl)piperazine dihydrochloride
  • 1-(Bis(4-fluorophenyl)methyl)-4-((2,3,4-trimethoxyphenyl)methyl)piperazine dihydrochloride
  • KB 2796
  • Lomerizine HCl
  • Lomerizine hydrochloride
  • UNII-3W473D5LIY

Systematic Name

  • Piperazine, 1-(bis(4-fluorophenyl)methyl)-4-((2,3,4-trimethoxyphenyl)methyl)-, dihydrochloride

Registry Numbers

CAS Registry Number

  • 101477-54-7

FDA UNII

  • 3W473D5LIY

System Generated Number

  • 0101477547

Molecular Formulas

Molecular Formula

  • C27-H30-F2-N2-O3.2Cl-H

Molecular Formula Fragments

  • C27-H30-F2-N2-O3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C27H30F2N2O3.2ClH/c1-32-24-13-8-21(26(33-2)27(24)34-3)18-30-14-16-31(17-15-30)25(19-4-9-22(28)10-5-19)20-6-11-23(29)12-7-20;;/h4-13,25H,14-18H2,1-3H3;2*1H

InChIKey

LOGVKVSFYBBUAJ-UHFFFAOYSA-N

Smiles

c1(c(c(CN2CCN(CC2)C(c2ccc(F)cc2)c2ccc(cc2)F)ccc1OC)OC)OC.Cl.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 706mg/kg (706mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Cardiovascular Drug Reviews. Vol. 8, Pg. 105, 1990.
mouse LD50 intravenous 44mg/kg (44mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Cardiovascular Drug Reviews. Vol. 8, Pg. 105, 1990.
mouse LD50 oral 300mg/kg (300mg/kg)   European Patent Application. Vol. #159566,
mouse LD50 subcutaneous > 1200mg/kg (1200mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Cardiovascular Drug Reviews. Vol. 8, Pg. 105, 1990.
rat LD50 intravenous 27mg/kg (27mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Cardiovascular Drug Reviews. Vol. 8, Pg. 105, 1990.
rat LD50 oral 307mg/kg (307mg/kg)   Cardiovascular Drug Reviews. Vol. 8, Pg. 105, 1990.
rat LD50 subcutaneous 882mg/kg (882mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Cardiovascular Drug Reviews. Vol. 8, Pg. 105, 1990.