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Substance Name: Sematilide hydrochloride [USAN]
RN: 101526-62-9
UNII: 1B8MC21ZI2
InChIKey: OKXAJGDKHKNFAX-UHFFFAOYSA-N

Classification Codes

  • Cardiac Depressant (Anti-Arrhythmic)
  • Drug / Therapeutic Agent

Molecular Formula

  • C14-H23-N3-O3-S.Cl-H

Molecular Weight

  • 349.881
 
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Names and Synonyms

Name of Substance

  • Sematilide
  • Sematilide hydrochloride [USAN]
  • Sematilide monohydrochloride

Synonyms

  • Benzamide, N-(2-(diethylamino)ethyl)-4-((methylsulfonyl)amino)-, monohydrochloride
  • CK 1752A
  • CK-1752A
  • N-(2-(Diethylamino)ethyl)-4-((methylsulfonyl)amino)benzamide monohydrochloride
  • N-(2-(Diethylamino)ethyl)-p-methanesulfonamidobenzamide monohydrochloride
  • Sematilide HCl
  • Sematilide hydrochloride
  • UNII-1B8MC21ZI2

Systematic Name

  • Benzamide, N-(2-(diethylamino)ethyl)-4-((methylsulfonyl)amino)-, monohydrochloride

Registry Numbers

CAS Registry Number

  • 101526-62-9

FDA UNII

  • 1B8MC21ZI2

System Generated Number

  • 0101526629

Molecular Formulas

Molecular Formula

  • C14-H23-N3-O3-S.Cl-H

Molecular Formula Fragments

  • C14-H23-N3-O3-S
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C14H23N3O3S.ClH/c1-4-17(5-2)11-10-15-14(18)12-6-8-13(9-7-12)16-21(3,19)20;/h6-9,16H,4-5,10-11H2,1-3H3,(H,15,18);1H

InChIKey

OKXAJGDKHKNFAX-UHFFFAOYSA-N

Smiles

c1(ccc(NS(C)(=O)=O)cc1)C(NCCN(CC)CC)=O.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 143mg/kg (143mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Cardiovascular Drug Reviews. Vol. 10, Pg. 182, 1992.
dog LD50 oral 500mg/kg (500mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Cardiovascular Drug Reviews. Vol. 10, Pg. 182, 1992.
mouse LD50 intravenous 96mg/kg (96mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Cardiovascular Drug Reviews. Vol. 10, Pg. 182, 1992.
mouse LD50 oral 1800mg/kg (1800mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Cardiovascular Drug Reviews. Vol. 10, Pg. 182, 1992.
rat LD50 intravenous 92mg/kg (92mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Cardiovascular Drug Reviews. Vol. 10, Pg. 182, 1992.
rat LD50 oral 3200mg/kg (3200mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Cardiovascular Drug Reviews. Vol. 10, Pg. 182, 1992.