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Substance Name: Lanoconazole [INN]
RN: 101530-10-3
UNII: 4E7858311F
InChIKey: ZRTQSJFIDWNVJW-WYMLVPIESA-N

Classification Codes

  • Agricultural Chemical
  • Drug / Therapeutic Agent
  • Fungicide, Bactericide, Wood Preservative
  • Reproductive Effect

Molecular Formula

  • C14-H10-Cl-N3-S2

Molecular Weight

  • 319.839
 
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Names and Synonyms

Name of Substance

  • Lanoconazole
  • Lanoconazole [INN]

Synonyms

  • (+-)-(E)-(4-(2-Chlorophenyl)-1,3-dithiolan-2-ylidene)-1-imidazolylacetonitrile
  • (+-)-alpha-((E)-4-(o-Chlorophenyl)-1,3-dithiolan-2-ylidene)imidazole-1-acetonitrile
  • (E)-alpha-(4-(2-Chlorophenyl)-1,3-dithiolan-2-ylidene)-1H-imidazole-1-acetonitrile
  • Astat
  • BRN 4819111
  • Lanoconazole
  • Latoconazole
  • NND-318
  • TJN-318
  • UNII-4E7858311F

Systematic Names

  • (+-)-alpha-((E)-4-(o-Chlorophenyl)-1,3-dithiolan-2-ylidene)imidazole-1-acetonitrile
  • 1H-Imidazole-1-acetonitrile, alpha-(4-(2-chlorophenyl)-1,3-dithiolan-2-ylidene)-, (alphaE)-
  • 1H-Imidazole-1-acetonitrile, alpha-(4-(2-chlorophenyl)-1,3-dithiolan-2-ylidene)-, (E)-(+-)-

Registry Numbers

CAS Registry Number

  • 101530-10-3

FDA UNII

  • 4E7858311F

Other Registry Number

  • 153222-93-6

System Generated Number

  • 0101530103

Structure Descriptors

InChI

1S/C14H10ClN3S2/c15-11-4-2-1-3-10(11)13-8-19-14(20-13)12(7-16)18-6-5-17-9-18/h1-6,9,13H,8H2/b14-12+

InChIKey

ZRTQSJFIDWNVJW-WYMLVPIESA-N

Smiles

c1ccc(c(c1)C2CS/C(=C(/C#N)\n3ccnc3)/S2)Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo subcutaneous 2gm/kg (2000mg/kg) BLOOD: NORMOCYTIC ANEMIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LIVER: OTHER CHANGES
Oyo Yakuri. Pharmacometrics. Vol. 43, Pg. 137, 1992.
mouse LD subcutaneous > 5gm/kg (5000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 43, Pg. 195, 1992.
mouse LD50 intraperitoneal 1743mg/kg (1743mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 43, Pg. 195, 1992.
mouse LD50 intraperitoneal 1743mg/kg (1743mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Oyo Yakuri. Pharmacometrics. Vol. 43, Pg. 195, 1992.
mouse LD50 oral 2715mg/kg (2715mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC
Oyo Yakuri. Pharmacometrics. Vol. 43, Pg. 195, 1992.
rat LD skin > 5gm/kg (5000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 43, Pg. 195, 1992.
rat LD subcutaneous > 5gm/kg (5000mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Oyo Yakuri. Pharmacometrics. Vol. 43, Pg. 195, 1992.
rat LD50 intraperitoneal 1655mg/kg (1655mg/kg) BEHAVIORAL: REGIDITY

AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Oyo Yakuri. Pharmacometrics. Vol. 43, Pg. 195, 1992.
rat LD50 oral 652mg/kg (652mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC
Oyo Yakuri. Pharmacometrics. Vol. 43, Pg. 195, 1992.