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Substance Name: Butenafine hydrochloride [USAN:JAN]
RN: 101827-46-7
UNII: R8XA2029ZI
InChIKey: LJBSAUIFGPSHCN-UHFFFAOYSA-N

Note

  • Studied on experimental dermatophytosis.

Molecular Formula

  • C23-H27-N.Cl-H

Molecular Weight

  • 353.9342
 

Classification Codes

  • Antifungal
  • Drug / Therapeutic Agent
  • Reproductive Effect
  • Skin / Eye Irritant
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Names and Synonyms

Name of Substance

  • Butenafine hydrochloride [USAN:JAN]

Synonyms

  • Butenafine HCl
  • Butenafine hydrochloride
  • KP-363
  • Mentax
  • Mentax-TC
  • N-((4-(1,1-Dimethylethyl)phenyl)methyl)-N-methyl-1-naphthalenemethanamine hydrochloride
  • N-(p-tert-Butylbenzyl)-N-methyl-1-naphthalenemethylamine hydrochloride
  • N-4-tert-Butylbenzyl-N-methyl-1-naphthalenemethylamine hydrochloride
  • UNII-R8XA2029ZI

Systematic Name

  • 1-Naphthalenemethanamine, N-((4-(1,1-dimethylethyl)phenyl)methyl)-N-methyl-, hydrochloride

Registry Numbers

CAS Registry Number

  • 101827-46-7

FDA UNII

  • R8XA2029ZI

System Generated Number

  • 0101827467

Molecular Formulas

Molecular Formula

  • C23-H27-N.Cl-H

Molecular Formula Fragments

  • C23-H27-N
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C23H27N.ClH/c1-23(2,3)21-14-12-18(13-15-21)16-24(4)17-20-10-7-9-19-8-5-6-11-22(19)20;/h5-15H,16-17H2,1-4H3;1H

InChIKey

LJBSAUIFGPSHCN-UHFFFAOYSA-N

Smiles

CC(C)(C)c1ccc(cc1)CN(C)Cc2cccc3c2cccc3.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 5gm/kg (5000mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 1551, 1990.
dog LD50 skin > 100mg/kg (100mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992.
mouse LD50 intravenous > 140mg/kg (140mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992.
mouse LD50 oral > 5gm/kg (5000mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 1539, 1990.
mouse LD50 skin > 800mg/kg (800mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992.
mouse LD50 subcutaneous > 200mg/kg (200mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992.
rat LD50 intravenous > 100mg/kg (100mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 1539, 1990.
rat LD50 oral > 4gm/kg (4000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992.
rat LD50 skin > 1gm/kg (1000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992.
rat LD50 subcutaneous > 150mg/kg (150mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992.
rat LDLo intraperitoneal 1gm/kg (1000mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 2589, 1990.