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Substance Name: Trastuzumab emtansine [USAN:INN]
RN: 1018448-65-1


  • Designed to deliver antimicrotubule agent DM1 to HER2-positive cells

    NCI: An antibody-drug conjugate (ADC) consisting of the recombinant anti-epidermal growth factor receptor 2 (HER2) monoclonal antibody trastuzumab conjugated to the maytansinoid DM1 via a nonreducible thioether linkage (MCC) with potential antineoplastic activity. The trastuzumab moiety of this ADC binds to HER2 on tumor cell surface surfaces; upon internalization, the DM1 moiety is released and binds to tubulin, thereby disrupting microtubule assembly/disassembly dynamics and inhibiting cell division and the proliferation of cancer cells that overexpress HER2. Linkage of antibody and drug through a nonreducible linker has been reported to contribute to the improved efficacy and reduced toxicity of this ADC compared to similar ADCs constructed with reducible linkers. (NCI Thesaurus)
  • Immunotoxin that consists of humanized monoclonal anti-HER2 antibody TRASTUZUMAB covalently linked to anti-microtubule agent MAYTANSINOID DM1 for treatment of metastatic breast cancer in patients who previously received trastuzumab and a TAXANES, separately or in combination.

Molecular Weight

  • 973.5557

Classification Codes

  • Antimitotic Agents
  • Antineoplastic Agents
  • Antineoplastic Agents, Immunological
  • Immunologic Factors
  • Immunotoxins
  • Noxae
  • Treatment of Cancer
  • Tubulin Modulators
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Links to Resources

Names and Synonyms

Name of Substance

  • Trastuzumab emtansine [USAN:INN]

MeSH Heading

  • Ado-Trastuzumab emtansine


  • Ado-trastuzumab emtansine
  • Kadcyla
  • PRO 132365
  • PRO132365
  • T-DM 1
  • T-DM1
  • Trastuzumab conjugate with emtasine
  • Trastuzumab emtansine
  • Trastuzumab-DM1
  • Trastuzumab-MCC-DM 1
  • Trastuzumab-MCC-DM1
  • Trastuzumab-MCC-DM1 antibody-drug conjugate

Systematic Name

  • Immunoglobulin G1, anti-(human p185neu receptor) (human-mouse monoclonal rhuMab HER2 gamma1-chain), disulfide with human-mouse monoclonal rhuMab HER2 light chain, dimer, tetraamide with N2'-(3-((1-((4-carboxycyclohexyl)methyl)-2,5-dioxo-3-pyrrolidinyl)thio)-1-oxopropyl)-N2'-deacetylmaytansine

Registry Numbers

CAS Registry Number

  • 1018448-65-1


  • SE2KH7T06F

System Generated Number

  • 1018448651

Structure Descriptors