Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Triacetin [USP:INN:BAN]
RN: 102-76-1
UNII: XHX3C3X673
InChIKey: URAYPUMNDPQOKB-UHFFFAOYSA-N

Note

  • A triglyceride that is used as an antifungal agent.

Molecular Formula

  • C9-H14-O6

Molecular Weight

  • 218.204
 

Classification Codes

  • Anti-Infective Agents
  • Antifungal
  • Antifungal Agents
  • Drug / Therapeutic Agent
  • Skin / Eye Irritant
  • Solvents

Names and Synonyms

Name of Substance

  • 1,2,3-Propanetriol triacetate
  • Acetic, 1,2,3-propanetriyl ester
  • Triacetin
  • Triacetin [USP:INN:BAN]

MeSH Heading

  • Triacetin

Synonyms

  • 1,2,3-Propanetriol triacetate
  • 1,2,3-Propanetriyl triacetate
  • 4-02-00-00253 (Beilstein Handbook Reference)
  • Acetin, tri-
  • AI3-00661
  • BRN 1792353
  • CCRIS 9355
  • EC 203-051-9
  • EINECS 203-051-9
  • Enzactin
  • FEMA No. 2007
  • FEMA Number 2007
  • Fungacetin
  • Glycerin triacetate
  • Glycerol triacetate
  • Glyceryl triacetate
  • Glyped
  • HSDB 585
  • Kesscoflex TRA
  • Kodaflex triacetin
  • NSC 4796
  • Triacetin
  • Triacetina
  • Triacetina [INN-Spanish]
  • Triacetine
  • Triacetine [INN-French]
  • Triacetinum
  • Triacetinum [INN-Latin]
  • Triacetyl glycerine
  • Triacetylglycerol
  • UNII-XHX3C3X673
  • Vanay

Systematic Names

  • 1,2,3-Propanetriol, 1,2,3-triacetate
  • 1,2,3-Propanetriol, triacetate
  • Acetin, tri-
  • Triacetin

Superlist Names

  • 1,2,3-Propanetriol triacetate
  • Acetin, tri-
  • Glyceryl triacetate
  • Triacetin

Registry Numbers

CAS Registry Number

  • 102-76-1

FDA UNII

  • XHX3C3X673

Other Registry Number

  • 2102168-03-4

System Generated Number

  • 0000102761

Structure Descriptors

InChI

1S/C9H14O6/c1-6(10)13-4-9(15-8(3)12)5-14-7(2)11/h9H,4-5H2,1-3H3

InChIKey

URAYPUMNDPQOKB-UHFFFAOYSA-N

Smiles

C(COC(C)=O)(COC(C)=O)OC(C)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 1500mg/kg (1500mg/kg)   Food and Cosmetics Toxicology. Vol. 16, Pg. 879, 1978.
frog LDLo oral 150mg/kg (150mg/kg)   Food and Cosmetics Toxicology. Vol. 16, Pg. 879, 1978.
guinea pig LDLo intramuscular 1740mg/kg (1740mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA Journal of Pharmacology and Experimental Therapeutics. Vol. 76, Pg. 189, 1942.
mouse LD50 intraperitoneal 1400mg/kg (1400mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: STIFFNESS

PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE
Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 22, Pg. 368, 1963.
mouse LD50 intravenous 1600mg/kg (1600mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Acta Physiologica Scandinavica. Vol. 40, Pg. 338, 1957.
mouse LD50 oral 1100mg/kg (1100mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: STIFFNESS
Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 22, Pg. 368, 1963.
mouse LD50 subcutaneous 2300mg/kg (2300mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Proceedings of the Society for Experimental Biology and Medicine. Vol. 46, Pg. 26, 1941.
rabbit LD50 intravenous 750mg/kg (750mg/kg)   Food and Cosmetics Toxicology. Vol. 16, Pg. 879, 1978.
rat LD50 intraperitoneal 2100mg/kg (2100mg/kg)   Food and Cosmetics Toxicology. Vol. 16, Pg. 879, 1978.
rat LD50 oral 3gm/kg (3000mg/kg)   AMA Archives of Industrial Health. Vol. 21, Pg. 28, 1960.
rat LD50 subcutaneous 2800mg/kg (2800mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Proceedings of the Society for Experimental Biology and Medicine. Vol. 46, Pg. 26, 1941.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 78 deg C   EXP
Boiling Point 259 deg C   EXP
log P (octanol-water) 0.25 (none)   EXP
Water Solubility 5.80E+04 mg/L 25 EXP
Vapor Pressure 0.00248 mm Hg 25 EXP
Henry's Law Constant 1.23E-08 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 7.81E-12 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.