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Substance Name: Moxetumomab pasudotox [USAN:INN]
RN: 1020748-57-5
UNII: 2NDX4B6N8F

Note

  • A second-generation pseudomonas exotoxin A-based immunotherapy targeting CD22-expressing hematologic malignancies.

    NCI: A recombinant immunotoxin consisting of the Fv portion of the anti-CD22 antibody covalently fused to a 38 KDa fragment of Pseudomonas exotoxin-A (PE38) with potential antineoplastic activity. The Fv portion of moxetumomab pasudotox binds to CD22, a cell surface receptor expressed on a variety of malignant B-cells, thereby delivering the toxin moiety PE38 directly to tumor cells. Once internalized, PE38 induces caspase-mediated apoptosis via a mechanism involving mitochondrial damage and blocks translational elongation by binding to elongation factor 2 (EF-2). Moxetumomab Pasudotox exhibits a greater affinity for CD22 than its predecessor, anti-CD22 immunotoxin CAT-3888 (BL22 immunotoxin), and hence may be more effective against tumor cells expressing lower levels of CD22. (NCI Thesaurus)

Molecular Formula

  • C2804-H4339-N783-O870-S14
 

Classification Codes

  • Antineoplastic Agents
  • Treatment of Cancer
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Links to Resources

Names and Synonyms

Name of Substance

  • Moxetumomab pasudotox [USAN:INN]

Synonyms

  • CAT 8015
  • CAT-8015
  • CAT-8015 immunotoxin
  • GCR 8015
  • GCR-8015
  • HA 22
  • HA22
  • Immunoglobulin Fv fragment fused to Pseudomonas toxin, anti-(Homo sapiens CD22 (sialic acid-binding Ig-like lectin 2, Siglec-2, SIGLEC2, Leu-14, B-lymphocyte cell adhesion molecule, BL-CAM)),Mus musculus monoclonal antibody disulfide stabilized Fv fragment with the variable heavy VH domain fused with the truncated form PE38 of Pseudomonas aeruginosa exotoxin A (VH-PE38), disulfide linked with the variable kappa domain (V-KAPPA)); VH-PE38 (1-476) comprising the VH domain (1-123) (methionyl -Mus musculus VH ((IGHV5-12-1*01 -(IGHD)-IG
  • Immunotoxin CAT-8015
  • Moxetumomab pasudotox
  • UNII-2NDX4B6N8F

Systematic Name

  • Immunoglobulin, anti-(human CD22 (antigen)) (synthetic Mus musculus CAT-8015 heavy chain variable region fragment) fusion protein with exotoxin PE38 (Pseudomonas fragment), disulfide with immunoglobulin, anti-(human CD22 (antigen)) (synthetic Mus musculus CAT-8015 light chain fragment)

Registry Numbers

CAS Registry Number

  • 1020748-57-5

FDA UNII

  • 2NDX4B6N8F

System Generated Number

  • 1020748575