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Substance Name: Pyrimidine, 2-amino-4-(2-dimethylaminoethoxy)-
RN: 102207-77-2
InChIKey: DJPLUEGVLBIDTL-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C8-H14-N4-O

Molecular Weight

  • 182.2256
 
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Names and Synonyms

Synonyms

  • 2-Amino-4-(2-dimethylaminoethoxy)pyrimidine
  • 2-Amino-4-dimethylaminoethoxypyrimidine
  • 4-25-00-03351 (Beilstein Handbook Reference)
  • BRN 0153890
  • OR-1549

Systematic Name

  • Pyrimidine, 2-amino-4-(2-dimethylaminoethoxy)-

Registry Numbers

CAS Registry Number

  • 102207-77-2

System Generated Number

  • 0102207772

Structure Descriptors

InChI

1S/C8H14N4O/c1-12(2)5-6-13-7-3-4-10-8(9)11-7/h3-4H,5-6H2,1-2H3,(H2,9,10,11)

InChIKey

DJPLUEGVLBIDTL-UHFFFAOYSA-N

Smiles

n1c(nc(cc1)OCCN(C)C)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 450mg/kg (450mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 106, Pg. 50, 1956.
dog LD50 oral 1500mg/kg (1500mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 106, Pg. 50, 1956.
mouse LD50 intraperitoneal 478mg/kg (478mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 106, Pg. 50, 1956.
mouse LD50 intravenous 252mg/kg (252mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 106, Pg. 50, 1956.
rabbit LD50 intravenous 440mg/kg (440mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 106, Pg. 50, 1956.
rabbit LD50 oral 3750mg/kg (3750mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 106, Pg. 50, 1956.
rat LD50 intraperitoneal 75mg/kg (75mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 106, Pg. 50, 1956.
rat LD50 oral 1500mg/kg (1500mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 106, Pg. 50, 1956.