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Substance Name: Olaratumab [USAN:INN]
RN: 1024603-93-7
UNII: TT6HN20MVF

Notes

  • A fully human immunoglobulin G subclass 1 monoclonal antibody targeting the platelet-derived growth factor receptor alpha for treatment of solid malignancies.

    NCI: A fully human IgG1 monoclonal antibody directed against the platelet-derived growth factor receptor alpha (PDGFR alpha) with potential antineoplastic activity. Olaratumab selectively binds to PDGFR alpha, .blocking the binding of its ligand, PDGF; signal transduction downstream of PDGFR through the MAPK and PI3K pathways is inhibited, which may result in inhibition of angiogenesis and tumor cell proliferation. Overexpressed by various cancer cell types, PDGFR is a transmembrane protein tyrosine kinase receptor, consisting of isoforms A and B, that is important in regulating cellular growth and differentiation and angiogenesis. (NCI Thesaurus)
  • An anti-platelet-derived growth factor receptor alpha monoclonal antibody.

Molecular Formula

  • Unspecified
 

Classification Codes

  • Antineoplastic Agents
  • Treatment of Solid Tumors

Names and Synonyms

Name of Substance

  • Olaratumab [USAN:INN]

Synonyms

  • anti-PDGFR alpha monoclonal antibody IMC-3G3
  • IMC 3G3
  • IMC-3G3
  • IMC3G3
  • Lartruvo
  • Olaratumab
  • UNII-TT6HN20MVF

Registry Numbers

CAS Registry Number

  • 1024603-93-7

FDA UNII

  • TT6HN20MVF

System Generated Number

  • 1024603937