|
|
|
Substance Name: Fostamatinib disodium
RN: 1025687-58-4
UNII: X9417132K8
InChIKey: HSYBQXDGYCYSGA-UHFFFAOYSA-L
Note
- A spleen tyrosine kinase (Syk) inhibitor, metabolized to 406.
NCI: /Fostamatinib disodium/ An orally available disodium salt of the Syk kinase inhibitor fostamatinib with potential anti-inflammatory and immunomodulating activities. Fostamatinib inhibits Syk kinase-mediated IgG Fc gamma receptor signaling, resulting in inhibition of the activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage. Syk kinase, widely expressed in hematopoietic cells, is a nonreceptor tyrosine kinase that is involved in coupling activated immunoreceptors to signal downstream events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis (NCI Thesaurus)
Molecular Formula
- C23-H26-F-N6-O9-P.2Na
Molecular Weight
- 624.4276
* denotes mobile formatted website
Links to Resources
NLM Resources (File Locators)
Other Resources (Internet Locators)
Search for this InChIKey on the Web
Names and Synonyms
Results Name
- Fostamatinib disodium
Name of Substance
- Fostamatinib disodium anhydrous
Synonyms
- R 788 sodium
- R 935788 sodium
- Tavalisse
- UNII-X9417132K8
Systematic Name
- 2H-Pyrido(3,2-b)-1,4-oxazin-3(4H)-one, 6-((5-fluoro-2-((3,4,5-trimethoxyphenyl)amino)-4-pyrimidinyl)amino)-2,2-dimethyl-4-((phosphonooxy)methyl)-, sodium salt (1:2)
Mixture Name
- Fostamatinib disodium
Registry Numbers
CAS Registry Number
- 1025687-58-4
FDA UNII
- X9417132K8
System Generated Number
- 1025687584
Molecular Formulas
Molecular Formula
- C23-H26-F-N6-O9-P.2Na
Molecular Formula Fragments
- C23-H26-F-N6-O9-P
- COMPONENT
- Na