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Substance Name: Fostamatinib disodium
RN: 1025687-58-4
UNII: X9417132K8
InChIKey: HSYBQXDGYCYSGA-UHFFFAOYSA-L

Note

  • A spleen tyrosine kinase (Syk) inhibitor, metabolized to 406.

    NCI: /Fostamatinib disodium/ An orally available disodium salt of the Syk kinase inhibitor fostamatinib with potential anti-inflammatory and immunomodulating activities. Fostamatinib inhibits Syk kinase-mediated IgG Fc gamma receptor signaling, resulting in inhibition of the activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage. Syk kinase, widely expressed in hematopoietic cells, is a nonreceptor tyrosine kinase that is involved in coupling activated immunoreceptors to signal downstream events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis (NCI Thesaurus)

Molecular Formula

  • C23-H26-F-N6-O9-P.2Na

Molecular Weight

  • 624.4276
 
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Names and Synonyms

Results Name

  • Fostamatinib disodium

Name of Substance

  • Fostamatinib disodium anhydrous

Synonyms

  • R 788 sodium
  • R 935788 sodium
  • Tavalisse
  • UNII-X9417132K8

Systematic Name

  • 2H-Pyrido(3,2-b)-1,4-oxazin-3(4H)-one, 6-((5-fluoro-2-((3,4,5-trimethoxyphenyl)amino)-4-pyrimidinyl)amino)-2,2-dimethyl-4-((phosphonooxy)methyl)-, sodium salt (1:2)

Mixture Name

  • Fostamatinib disodium

Registry Numbers

CAS Registry Number

  • 1025687-58-4

FDA UNII

  • X9417132K8

System Generated Number

  • 1025687584

Molecular Formulas

Molecular Formula

  • C23-H26-F-N6-O9-P.2Na

Molecular Formula Fragments

  • C23-H26-F-N6-O9-P
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C23H26FN6O9P.2Na/c1-23(2)21(31)30(11-38-40(32,33)34)20-14(39-23)6-7-17(28-20)27-19-13(24)10-25-22(29-19)26-12-8-15(35-3)18(37-5)16(9-12)36-4;;/h6-10H,11H2,1-5H3,(H2,32,33,34)(H2,25,26,27,28,29);;/q;2*+1/p-2

InChIKey

HSYBQXDGYCYSGA-UHFFFAOYSA-L

Smiles

[Na+].[Na+].COc1cc(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)N(COP(=O)([O-])[O-])c4n3)n2)cc(OC)c1OC