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Substance Name: Lifitegrast [USAN:INN]
RN: 1025967-78-5
UNII: 038E5L962W
InChIKey: JFOZKMSJYSPYLN-QHCPKHFHSA-N

Notes

  • An LFA-1 (LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1) antagonist that is used in the treatment of DRY EYE SYNDROMES.
  • An LFA-1 antagonist.

Molecular Formula

  • C29-H24-Cl2-N2-O7-S

Molecular Weight

  • 615.4876
 

Classification Codes

  • Ophthalmic Solutions
  • Pharmaceutical Solutions
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Names and Synonyms

Name of Substance

  • Lifitegrast [USAN:INN]

Synonyms

  • (2S)-2-(((2-(Benzofuran-6-ylcarbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinolin-6- yl)carbonyl)amino)-3-(3-(methylsulfonyl)phenyl)propanoic acid
  • L-Phenylalanine, N-((2-(6-benzofuranylcarbonyl)-5,7-dichloro-1,2,3,4-tetrahydro-6-isoquinolinyl)carbonyl)-3-(methylsulfonyl)-
  • Lifitegrast
  • SAR 1118
  • SAR-1118
  • UNII-038E5L962W
  • Xiidra

Registry Numbers

CAS Registry Number

  • 1025967-78-5

FDA UNII

  • 038E5L962W

Other Registry Numbers

  • 1356856-75-1
  • 915397-62-5

System Generated Number

  • 1025967785

Structure Descriptors

InChI

1S/C29H24Cl2N2O7S/c1-41(38,39)20-4-2-3-16(11-20)12-23(29(36)37)32-27(34)25-22(30)13-19-15-33(9-7-21(19)26(25)31)28(35)18-6-5-17-8-10-40-24(17)14-18/h2-6,8,10-11,13-14,23H,7,9,12,15H2,1H3,(H,32,34)(H,36,37)/t23-/m0/s1

InChIKey

JFOZKMSJYSPYLN-QHCPKHFHSA-N

Smiles

CS(=O)(=O)c1cccc(c1)C[C@@H](C(=O)O)NC(=O)c2c(cc3c(c2Cl)CCN(C3)C(=O)c4ccc5ccoc5c4)Cl