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Substance Name: Trimecaine Monohydrochloride
RN: 1027-14-1
UNII: 5491FXS1NB
InChIKey: KOOGJYYOMPUGCW-UHFFFAOYSA-N

Note

  • Acetanilide derivative used as a local anesthetic.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C15-H24-N2-O.Cl-H

Molecular Weight

  • 284.8285
 
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Names and Synonyms

Name of Substance

  • Trimecaine Monohydrochloride

Synonyms

  • 2-Diethylamino-2',4',6'-trimethylacetanilide hydrochloride
  • Diethylaminoacetyl 2,4,6-trimethyl-aniline hydrochloride
  • EINECS 213-836-8
  • Mesidicaine hydrochloride
  • Mesocain
  • Mesocaine
  • Mesokain
  • N-sym-Trimethylphenyldiethylaminoacetamide hydrochloride
  • Trimecaine HCl
  • Trimecaine hydrochloride
  • Trimekain hydrochloride
  • UNII-5491FXS1NB

Systematic Names

  • 2-(Diethylamino)-N-(2,4,6-trimethylphenyl)acetamide monohydrochloride
  • Acetamide, 2-(diethylamino)-N-(2,4,6-trimethylphenyl)-, monohydrochloride (9CI)
  • Acetanilide, 2-(diethylamino)-2',4',6'-trimethyl-, hydrochloride
  • Acetanilide, 2-(diethylamino)-2',4',6'-trimethyl-, monohydrochloride (8CI)

Registry Numbers

CAS Registry Number

  • 1027-14-1

FDA UNII

  • 5491FXS1NB

Related Registry Number

  • 616-68-2 (Parent)

System Generated Number

  • 0001027141

Molecular Formulas

Molecular Formula

  • C15-H24-N2-O.Cl-H

Molecular Formula Fragments

  • C15-H24-N2-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C15H24N2O.ClH/c1-6-17(7-2)10-14(18)16-15-12(4)8-11(3)9-13(15)5;/h8-9H,6-7,10H2,1-5H3,(H,16,18);1H

InChIKey

KOOGJYYOMPUGCW-UHFFFAOYSA-N

Smiles

CC[NH+](CC)CC(=O)Nc1c(cc(cc1C)C)C.[Cl-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 172mg/kg (172mg/kg)   Acta Facultatis Pharmaceuticae, Universitatis Comenianae. Vol. 29, Pg. 81, 1976.
mouse LD50 intravenous 50mg/kg (50mg/kg) BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA
Farmakologiya i Toksikologiya Vol. 25, Pg. 731, 1962.
mouse LD50 subcutaneous 295mg/kg (295mg/kg)   "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989Vol. 11, Pg. 1526, 1989.
rabbit LD50 intraperitoneal 95mg/kg (95mg/kg)   Drug Metabolism and Drug Interactions. Vol. 9, Pg. 321, 1991.