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Substance Name: Nerisopam [INN]
RN: 102771-12-0
UNII: 18Q4O339AG
InChIKey: WWQDEXGFYVSTCX-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C18-H19-N3-O2

Molecular Weight

  • 309.367
 
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Names and Synonyms

Name of Substance

  • GYKI 52322
  • Nerisopam [INN]

Synonyms

  • 1-(4-Aminophenyl)-4-methyl-7,8-dimethoxy-5H-2,3-benzodiazepine
  • 1-(4-Aminophenyl)-7,8-dimethoxy-4-methyl-5H-2,3-benzodiazepine
  • GYKI 52322
  • Nerisopam
  • UNII-18Q4O339AG

Systematic Names

  • 1-(p-Aminophenyl)-7,8-dimethoxy-4-methyl-5H-2,3-benzodiazepine
  • 5H-2,3-Benzodiazepine, 1-(4-aminophenyl)-7,8-dimethoxy-4-methyl-
  • Benzenamine, 4-(7,8-dimethoxy-4-methyl-5H-2,3-benzodiazepin-1-yl)- (9CI)

Registry Numbers

CAS Registry Number

  • 102771-12-0

FDA UNII

  • 18Q4O339AG

System Generated Number

  • 0102771120

Structure Descriptors

InChI

1S/C18H19N3O2/c1-11-8-13-9-16(22-2)17(23-3)10-15(13)18(21-20-11)12-4-6-14(19)7-5-12/h4-7,9-10H,8,19H2,1-3H3

InChIKey

WWQDEXGFYVSTCX-UHFFFAOYSA-N

Smiles

c12cc(OC)c(cc1C(=NN=C(C2)C)c1ccc(cc1)N)OC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 182mg/kg (182mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Arzneimittel-Forschung. Drug Research. Vol. 39, Pg. 894, 1989.
mouse LD50 oral 275mg/kg (275mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Arzneimittel-Forschung. Drug Research. Vol. 39, Pg. 894, 1989.
rat LD50 intraperitoneal 108mg/kg (108mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Arzneimittel-Forschung. Drug Research. Vol. 39, Pg. 894, 1989.
rat LD50 oral 128mg/kg (128mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Arzneimittel-Forschung. Drug Research. Vol. 39, Pg. 894, 1989.