Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Capmatinib [USAN:INN]
RN: 1029712-80-8
UNII: TY34L4F9OZ
InChIKey: LIOLIMKSCNQPLV-UHFFFAOYSA-N

Note

  • A c-MET kinase inhibitor

    NCI: An orally bioavailable inhibitor of the proto-oncogene c-Met (hepatocyte growth factor receptor [HGFR]) with potential antineoplastic activity. Capmatinib selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays key roles in tumor cell proliferation, survival, invasion, metastasis, and tumor angiogenesis. (NCI Thesaurus)

Molecular Formula

  • C23-H17-F-N6-O

Molecular Weight

  • 412.4263
 

Classification Code

  • Antineoplastic
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Results Name

  • Capmatinib [USAN:INN]

Name of Substance

  • Capmatinib [USAN:INN]
  • Capmatinib [USAN]
  • INC-280

Synonyms

  • Capmatinib
  • INC280
  • INCB 28060
  • INCB28060
  • NVP-INC280-NX
  • UNII-TY34L4F9OZ

Registry Numbers

CAS Registry Number

  • 1029712-80-8

FDA UNII

  • TY34L4F9OZ

System Generated Number

  • 1029712808

Structure Descriptors

InChI

1S/C23H17FN6O/c1-25-22(31)18-6-5-16(11-19(18)24)21-13-28-23-27-12-17(30(23)29-21)10-14-4-7-20-15(9-14)3-2-8-26-20/h2-9,11-13H,10H2,1H3,(H,25,31)

InChIKey

LIOLIMKSCNQPLV-UHFFFAOYSA-N

Smiles

CNC(=O)c1ccc(cc1F)c2cnc3ncc(Cc4ccc5ncccc5c4)n3n2