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Substance Name: Acetanilide [NF]
RN: 103-84-4
UNII: SP86R356CC
InChIKey: FZERHIULMFGESH-UHFFFAOYSA-N

Note

  • A phenylacetamide.

Molecular Formula

  • C8-H9-N-O

Molecular Weight

  • 135.1651
 

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data

Names and Synonyms

Name of Substance

  • Acetamide, N-phenyl-
  • Acetanilid
  • Acetanilide
  • Acetanilide [NF]
  • N-Phenylacetamide

Synonyms

  • Acetamide, N-phenyl-
  • Acetamidobenzene
  • Acetanil
  • Acetanilid
  • Acetanilide
  • Acetic acid amide, N-phenyl-
  • Acetic acid anilide
  • Acetoanilide
  • Acetylaminobenzene
  • Acetylaniline
  • AI3-01045
  • AN [Analgesic]
  • Aniline, N-acetyl-
  • Antifebrin
  • Benzenamine, N-acetyl-
  • Caswell No. 003E
  • CCRIS 4452
  • EINECS 203-150-7
  • HSDB 2665
  • N-Acetylaniline
  • N-Phenylacetamide
  • NSC 7636
  • Phenalgene
  • Phenalgin
  • UNII-SP86R356CC
  • USAF EK-3

Systematic Names

  • Acetamide, N-phenyl-
  • Acetanilide

Superlist Names

  • Acetamide, N-phenyl-
  • Acetanilide

Registry Numbers

CAS Registry Number

  • 103-84-4

FDA UNII

  • SP86R356CC

System Generated Number

  • 0000103844

Structure Descriptors

InChI

InChI=1S/C8H9NO/c1-7(10)9-8-5-3-2-4-6-8/h2-6H,1H3,(H,9,10)

InChIKey

FZERHIULMFGESH-UHFFFAOYSA-N

Smiles

CC(=O)Nc1ccccc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intravenous 8500ug/kg (8.5mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 30, Pg. 91, 1941.
cat LDLo oral 250mg/kg (250mg/kg)   Journal of the American Pharmaceutical Association. Vol. 28, Pg. 70, 1939.
dog LDLo intravenous 300mg/kg (300mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1290, 1935.
dog LDLo oral 500mg/kg (500mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1290, 1935.
guinea pig LDLo oral 200mg/kg (200mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1290, 1935.
human TDLo oral 14mg/kg/D (14mg/kg) BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"		 "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 62, 1969.
man LDLo oral 56mg/kg/H-I (56mg/kg) GASTROINTESTINAL: DECREASED MOTILITY OR CONSTIPATION

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"		 American Journal of the Medical Sciences. Vol. 122, Pg. 770, 1901.
man LDLo unreported 59mg/kg (59mg/kg)   "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
man TDLo oral 405mg/kg (405mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: SLEEP		 JAMA, Journal of the American Medical Association. Vol. 12, Pg. 103, 1889.
mouse LD50 intraperitoneal 500mg/kg (500mg/kg)   National Technical Information Service. Vol. AD277-689,
mouse LD50 oral 1210mg/kg (1210mg/kg)   Toxicology and Applied Pharmacology. Vol. 19, Pg. 20, 1971.
rabbit LDLo oral 1500mg/kg (1500mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE Journal of Pharmacology and Experimental Therapeutics. Vol. 49, Pg. 466, 1933.
rat LD50 intraperitoneal 540mg/kg (540mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 48, Pg. 204, 1959.
rat LD50 oral 800mg/kg (800mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 54, Pg. 159, 1935.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 114.3 deg C   EXP
Boiling Point 304 deg C   EXP
pKa Dissociation Constant 0.5 (none) 25 EXP
log P (octanol-water) 1.16 (none)   EXP
Water Solubility 6390 mg/L 25 EXP
Henry's Law Constant 5.57E-09 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.25E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.