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Substance Name: Acetanilide [NF]
RN: 103-84-4
UNII: SP86R356CC
InChIKey: FZERHIULMFGESH-UHFFFAOYSA-N
Note
- A phenylacetamide; use ACETANILIDES for the plural group meaning of the singular term.
Molecular Formula
- C8-H9-N-O
Molecular Weight
- 135.1651
- All
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- Registry Numbers
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- Toxicity
- Physical Properties
Classification Codes
- Drug / Therapeutic Agent
- Human Data
- Mutation Data
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Names and Synonyms
Name of Substance
- Acetamide, N-phenyl-
- Acetanilid
- Acetanilide
- Acetanilide [NF]
- N-Phenylacetamide
Synonyms
- Acetamide, N-phenyl-
- Acetamidobenzene
- Acetanil
- Acetanilid
- Acetanilide
- Acetic acid amide, N-phenyl-
- Acetic acid anilide
- Acetoanilide
- Acetylaminobenzene
- Acetylaniline
- AI3-01045
- AN [Analgesic]
- Aniline, N-acetyl-
- Antifebrin
- Benzenamine, N-acetyl-
- Caswell No. 003E
- CCRIS 4452
- EINECS 203-150-7
- HSDB 2665
- N-Acetylaniline
- N-Phenylacetamide
- NSC 7636
- Phenalgene
- Phenalgin
- UNII-SP86R356CC
- USAF EK-3
Systematic Names
- Acetamide, N-phenyl-
- Acetanilide
Superlist Names
- Acetamide, N-phenyl-
- Acetanilide
Registry Numbers
CAS Registry Number
- 103-84-4
FDA UNII
- SP86R356CC
System Generated Number
- 0000103844
Structure Descriptors
InChI
InChI=1S/C8H9NO/c1-7(10)9-8-5-3-2-4-6-8/h2-6H,1H3,(H,9,10)InChIKey
FZERHIULMFGESH-UHFFFAOYSA-NSmiles
CC(=O)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LDLo | intravenous | 8500ug/kg (8.5mg/kg) | Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 30, Pg. 91, 1941. | |
| cat | LDLo | oral | 250mg/kg (250mg/kg) | Journal of the American Pharmaceutical Association. Vol. 28, Pg. 70, 1939. | |
| dog | LDLo | intravenous | 300mg/kg (300mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1290, 1935. | |
| dog | LDLo | oral | 500mg/kg (500mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1290, 1935. | |
| guinea pig | LDLo | oral | 200mg/kg (200mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1290, 1935. | |
| human | TDLo | oral | 14mg/kg/D (14mg/kg) | BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN LUNGS, THORAX, OR RESPIRATION: CYANOSIS KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" | "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 62, 1969. |
| man | LDLo | oral | 56mg/kg/H-I (56mg/kg) | GASTROINTESTINAL: DECREASED MOTILITY OR CONSTIPATION BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" | American Journal of the Medical Sciences. Vol. 122, Pg. 770, 1901. |
| man | LDLo | unreported | 59mg/kg (59mg/kg) | "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970. | |
| man | TDLo | oral | 405mg/kg (405mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION LUNGS, THORAX, OR RESPIRATION: CYANOSIS BEHAVIORAL: SLEEP | JAMA, Journal of the American Medical Association. Vol. 12, Pg. 103, 1889. |
| mouse | LD50 | intraperitoneal | 500mg/kg (500mg/kg) | National Technical Information Service. Vol. AD277-689, | |
| mouse | LD50 | oral | 1210mg/kg (1210mg/kg) | Toxicology and Applied Pharmacology. Vol. 19, Pg. 20, 1971. | |
| rabbit | LDLo | oral | 1500mg/kg (1500mg/kg) | PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE | Journal of Pharmacology and Experimental Therapeutics. Vol. 49, Pg. 466, 1933. |
| rat | LD50 | intraperitoneal | 540mg/kg (540mg/kg) | Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 48, Pg. 204, 1959. | |
| rat | LD50 | oral | 800mg/kg (800mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 54, Pg. 159, 1935. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 114.3 | deg C | EXP | |
| Boiling Point | 304 | deg C | EXP | |
| pKa Dissociation Constant | 0.5 | (none) | 25 | EXP |
| log P (octanol-water) | 1.16 | (none) | EXP | |
| Water Solubility | 6390 | mg/L | 25 | EXP |
| Henry's Law Constant | 5.57E-09 | atm-m3/mole | 25 | EST |
| Atmospheric OH Rate Constant | 1.25E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.