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Substance Name: Acetaminophen [USP:JAN]
RN: 103-90-2
UNII: 362O9ITL9D
InChIKey: RZVAJINKPMORJF-UHFFFAOYSA-N

Note

  • Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.

Molecular Formula

  • C8-H9-N-O2

Molecular Weight

  • 151.1641
 

Classification Codes

Classification Codes

  • Analgesic
  • Analgesics
  • Analgesics, Non-Narcotic
  • Antipyretic
  • Antipyretics
  • Central Nervous System Agents
  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Peripheral Nervous System Agents
  • Reproductive Effect
  • Sensory System Agents
  • Tumor Data

Superlist Classification Code

  • Overall Carcinogenic Evaluation: Group 3

Names and Synonyms

Name of Substance

  • Acetaminophen
  • Acetaminophen [USP:JAN]

MeSH Heading

  • Acetaminophen

Synonyms

  • 222 AF
  • 4'-Hydroxyacetanilide
  • 4-(Acetylamino)phenol
  • 4-13-00-01091 (Beilstein Handbook Reference)
  • 4-Acetamidophenol
  • 4-Hydroxyanilid kyseliny octove
  • 4-Hydroxyanilid kyseliny octove [Czech]
  • A-Per
  • A.F. Anacin
  • Abenol
  • Abensanil
  • Abrol
  • Abrolet
  • Acamol
  • Acenol
  • Acenol (pharmaceutical)
  • Acephen
  • Acertol
  • Acetaco
  • Acetagesic
  • Acetalgin
  • Acetamide, N-(p-hydroxyphenyl)-
  • Acetaminofen
  • Acetaminophen
  • Acetamol
  • Acetanilide, 4'-hydroxy-
  • Acetofen
  • Actron
  • Afebrin
  • Afebryl
  • Aferadol
  • Algesidal
  • Algina
  • Algomol
  • Algotropyl
  • Alpiny
  • Alvedon
  • Amadil
  • Anacin-3
  • Anadin dla dzieci
  • Anaflon
  • Analter
  • Andox
  • Anelix
  • Anhiba
  • Anti-Algos
  • Antidol
  • Apacet
  • Apamide
  • APAP
  • Apitrelal
  • Arfen
  • Asetam
  • Asomal
  • Aspac
  • Asplin
  • Atasol
  • Atralidon
  • Babikan
  • Bacetamol
  • Banesin
  • Ben-u-ron
  • Benmyo
  • Biocetamol
  • Cadafen
  • Calapol
  • Calmanticold
  • Calpol
  • Capital with codeine
  • Captin
  • Causalon
  • CCRIS 3
  • Cefalex
  • Children's Acetaminophen Elixir Drops
  • Children's Acetaminophen Elixir Solution
  • Children's Acetaminophen Oral Solution
  • Children's Tylenol Chewable
  • Claradol Codeine
  • Clixodyne
  • Cod-Acamol Forte
  • Codabrol
  • Codalgin
  • Codapane
  • Codicet
  • Codisal
  • Codisal Forte
  • Codoliprane
  • Codral Pain Relief
  • Cofamol
  • Contra-Schmerz P
  • Cosutone
  • Crocin
  • Croix Blanche
  • Cuponol
  • Curadon
  • Curpol
  • Custodial
  • Dafalgan
  • Dafalgan Codeine
  • Darocet
  • Datril
  • Daygrip
  • Deminofen
  • Democyl
  • Demogripal
  • Desfebre
  • Dhamol
  • Dial-a-gesic
  • Dirox
  • Disprol
  • Dol-Stop
  • Dolcor
  • Dolefin
  • Dolegrippin
  • Dolgesic
  • Doliprane
  • Dolko
  • Dolofugin
  • Doloreduct
  • Dolorfug
  • Dolorol Forte
  • Dolorstop
  • Dolotec
  • Dolprone
  • Dorocoff
  • Dresan
  • Dristancito
  • Duaneo
  • Duorol
  • Duracetamol
  • Durapan
  • Dymadon
  • Dymadon Co
  • Dymadon Forte
  • EC 203-157-5
  • Ecosetol
  • EINECS 203-157-5
  • Enelfa
  • Eneril
  • Eu-Med
  • Excipain
  • Exdol
  • Fanalgic
  • Farmadol
  • Febranine
  • Febrectal
  • Febrectol
  • Febrex
  • Febricet
  • Febridol
  • Febrilix
  • Febrin
  • Febro-gesic
  • Febrolin
  • Fendon
  • Fensum
  • Fepanil
  • Fever All
  • Finimal
  • Finiweh
  • Flexsure
  • Fluparmol
  • Fortalidon P
  • Freka-cetamol
  • Gattaphen T
  • Gelocatil
  • Geluprane
  • Geralgine-P
  • Gripin Bebe
  • Grippostad
  • Gynospasmine
  • Hedex
  • Helon N
  • Homoolan
  • HSDB 3001
  • Ildamol
  • Inalgex
  • Infadrops
  • Infants' Feverall
  • Influbene N
  • Injectapap
  • Junior Disprol
  • Kataprin
  • Kinder Finimal
  • Kratofin simplex
  • Labamol
  • Lekadol
  • Lemgrip
  • Lemsip
  • Lestemp
  • Liquagesic
  • Liquigesic Co
  • Lonarid
  • Lonarid Mono
  • Lupocet
  • Lyteca
  • Magnidol
  • Malex N
  • Malgis
  • Malidens
  • Maxadol
  • Medinol Paediatric
  • Medocodene
  • Melabon Infantil
  • Mexalen
  • Migraleve Yellow
  • Minafen
  • Minoset
  • Miralgin
  • Momentum
  • Mono Praecimed
  • Multin
  • N-(4-Hydroxyphenyl)acetamide
  • N-(4-Hydroxyphenyl)acetanilide
  • N-Acetyl-p-aminophenol
  • Naprinol
  • NCI-C55801
  • NCX 701
  • NEBS
  • Neo-Fepramol
  • NeoCitran
  • Neodol
  • Neodolito
  • Neopap
  • Neuridon
  • New Cortal for Children
  • NilnOcen
  • Nina
  • No-Febril
  • Nodolex
  • Noral
  • NSC 109028
  • Ofirmev
  • Oltyl
  • Oralgan
  • Ortensan
  • Oxycocet
  • p-Acetamidophenol
  • p-Acetaminophenol
  • p-Acetylaminophenol
  • p-Hydroxyacetanilide
  • Paceco
  • Pacemo
  • Pacemol
  • Pacet
  • Pacimol
  • Paedialgon
  • Paedol
  • Paldesic
  • Pamol
  • Panacete
  • Panadeine
  • Panadeine Co
  • Panadiene
  • Panado-Co
  • Panado-Co Caplets
  • Panadol
  • Panamax
  • Panasorbe
  • Panets
  • Panodil
  • Pantalgin
  • Para-Suppo
  • Para-Tabs
  • Paracemol
  • Paracenol
  • Paracet
  • Paracetamol
  • Paracetamol AL
  • Paracetamol Antipanin P
  • Paracetamol Basics
  • Paracetamol BC
  • Paracetamol Dr. Schmidgall
  • Paracetamol Fecofar
  • Paracetamol Genericon
  • Paracetamol Hanseler
  • Paracetamol Harkley
  • Paracetamol Heumann
  • Paracetamol Hexal
  • Paracetamol Italfarmaco
  • Paracetamol Nycomed
  • Paracetamol PB
  • Paracetamol Raffo
  • Paracetamol Ratiopharm
  • Paracetamol Rosch
  • Paracetamol Saar
  • Paracetamol SmithKline Beecham
  • Paracetamol Stada
  • Paracetamol von ct
  • Paracetamol Winthrop
  • Paracetamol [INN:BAN]
  • Paracetamolo
  • Paracetamolo [Italian]
  • Paracetamolum
  • Paracetamolum [INN-Latin]
  • Paracetol
  • Paracin
  • Paracod
  • Paracodol
  • Parador
  • Paradrops
  • Parakapton
  • Parake
  • Paralen
  • Paralief
  • Paralink
  • Paralyoc
  • Paramol
  • Paramolan
  • Paranox
  • Parasedol
  • Parasin
  • Parcetol
  • Parmol
  • Parogal
  • Paroma
  • PCM Paracetamol Lichtenstein
  • Pe-Tam
  • Pediapirin
  • Pediatrix
  • Percocet-5
  • Percocet-Demi
  • Perdolan Mono
  • Perfalgan
  • Phenaphen
  • Phenaphen W/Codeine
  • Phenipirin
  • Phogoglandin
  • Pinex
  • Piramin
  • Pirinasol
  • Plicet
  • Polmofen
  • Predimol
  • Predualito
  • Prodol
  • Prontina
  • Puernol
  • Pulmofen
  • Pyregesic-C
  • Pyrigesic
  • Pyrinazine
  • Pyromed
  • Reliv
  • Remedol
  • Resfenol
  • Rockamol Plus
  • Rounox
  • RubieMol
  • Rubophen
  • Rupemol
  • Salzone
  • Sanicet
  • Sanicopyrine
  • Scanol
  • Scentalgyl
  • Scherzatabletten Rezeptur 534
  • Schmerzex
  • Sedalito
  • Semolacin
  • Servigesic
  • Seskamol
  • Setakop
  • Setamol
  • Setol
  • Sifenol
  • Sinaspril
  • Sinedol
  • Sinmol
  • Spalt fur die nacht
  • Spalt N
  • St Joseph Aspirin-Free
  • St Joseph Aspirin-Free for Children
  • Stanback
  • Stopain
  • Sunetheton
  • Supadol mono
  • Supofen
  • Suppap
  • Supramol-M
  • Tabalgin
  • Tachiprina
  • Tapar
  • Tazamol
  • Tempra
  • Termacet
  • Termalgin
  • Termalgine
  • Termofren
  • Tiffy
  • Titralgan
  • Toximer P
  • Tralgon
  • Treupel mon
  • Treupel N
  • Treuphadol
  • Tricoton
  • Tussapap
  • Tylenol
  • Tylenol (caplet)
  • Tylenol (geltab)
  • Tylenol 8-Hour
  • Tylex
  • Tylex CD
  • Tylol
  • Tymol
  • UNII-362O9ITL9D
  • Upsanol
  • Utragin
  • Valadol
  • Valgesic
  • Veralgina
  • Vermidon
  • Verpol
  • Viclor Richet
  • Vips
  • Viruflu
  • Vivimed
  • Volpan
  • Zatinol
  • Zolben

Systematic Names

  • Acetamide, N-(4-hydroxyphenyl)-
  • Acetaminophen
  • Acetanilide, 4'-hydroxy-
  • Paracetamol

Superlist Names

  • Acetaminophen
  • DEA No. 9804
  • Paracetamol
  • Tylenol

Mixture Names

  • Actifed Plus
  • Anexsia
  • Aspirin-Free Anacin
  • Bayer Select Allergy-Sinus
  • Bayer Select Head Cold
  • Bayer Select Headache Pain
  • Bayer Select Menstrual Multi-Symptom
  • Bayer Select Sinus Pain Relief
  • Contac Cough & Sore Throat Formula
  • Coricidin
  • Coricidin D
  • Coricidin Sinus
  • Darvocet-N
  • Demilets
  • DHCplus
  • Dristan Cold No Drowsiness
  • Drixoral Cold & Flu
  • Drixoral Sinus
  • Empracet
  • Endecon
  • Hy-Phen
  • Hycomine Compound
  • Intensin
  • Jin Gang
  • Liquiprin
  • Midol Maximum Strength
  • Midol PM Night Time Formula
  • Midol Regular Strength
  • Midol Teen Formula
  • Naldegesic
  • Ornex Severe Cold Formula
  • Percocet
  • Percogesic with Codeine
  • Propacet
  • Quiet World
  • Rhinex D-Lay Tablets
  • Robitussin Night Relief
  • Sine-Aid, Maximum Strength
  • Sine-Off Sinus Medicine Caplets
  • Sinubid
  • St. Joseph Cold Tablets for Children
  • Sudafed Cold and Cough
  • Sudafed Severe Cold Formula
  • Sudafed Sinus
  • Supac
  • Talacen
  • TheraFlu
  • Triaminic Sore Throat Formula
  • Tylenol Allergy Sinus
  • Tylox
  • Vanquish
  • Vicodin

Registry Numbers

CAS Registry Number

  • 103-90-2

FDA UNII

  • 362O9ITL9D

Other Registry Numbers

  • 1430221-00-3
  • 719293-04-6
  • 8055-08-1

System Generated Number

  • 0000103902

Structure Descriptors

InChI

1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)

InChIKey

RZVAJINKPMORJF-UHFFFAOYSA-N

Smiles

c1(ccc(cc1)O)NC(=O)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child LDLo oral 50mg/kg (50mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

CARDIAC: OTHER CHANGES
American Journal of Emergency Medicine. Vol. 6, Pg. 510, 1988.
child LDLo oral 140mg/kg/7D-I (140mg/kg) BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)"

BEHAVIORAL: COMA

LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL"
Medical Journal of Australia. Vol. 171, Pg. 472, 1999.
child LDLo oral 360mg/kg/2D (360mg/kg) LIVER: OTHER CHANGES

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"

GASTROINTESTINAL: NAUSEA OR VOMITING
Journal of Pediatrics. Vol. 92, Pg. 832, 1978.
child TDLo oral 591mg/kg/2D-I (591mg/kg) BLOOD: APLASTIC ANEMIA

LIVER: LIVER FUNCTION TESTS IMPAIRED

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
Clinical Pediatrics Vol. 33, Pg. 42, 1994.
child TDLo oral 801mg/kg (801mg/kg) LIVER: OTHER CHANGES

GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: GENERAL ANESTHETIC
Pediatrics. Vol. 61, Pg. 68, 1978.
dog LDLo intravenous 826mg/kg (826mg/kg) BEHAVIORAL: ANALGESIA Archives Internationales de Pharmacodynamie et de Therapie. Vol. 149, Pg. 571, 1964.
dog LDLo oral 2gm/kg (2000mg/kg) BLOOD: CHANGES IN SPLEEN

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 24, Pg. 602, 1993.
frog LDLo subcutaneous 50mg/kg (50mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 33, Pg. 216, 1894.
guinea pig LD50 oral 2620mg/kg (2620mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: TREMOR
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 47, Pg. 479, 1958.
human LDLo oral 143mg/kg (143mg/kg) BEHAVIORAL: GENERAL ANESTHETIC British Medical Journal. Vol. 282, Pg. 199, 1981.
human LDLo oral 357mg/kg (357mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: ANOREXIA (HUMAN

BEHAVIORAL: COMA
Lancet. Vol. 1, Pg. 66, 1973.
infant TDLo oral 1440mg/kg/6D (1440mg/kg)   American Journal of Diseases of Children. Vol. 137, Pg. 386, 1983.
infant TDLo oral 1440mg/kg/6D (1440mg/kg) BEHAVIORAL: IRRITABILITY

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
American Journal of Diseases of Children. Vol. 137, Pg. 386, 1983.
mammal (species unspecified) LD50 unreported 891mg/kg (891mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 48(6), Pg. 22, 1983.
mammal (species unspecified) LDLo oral 512mg/kg (512mg/kg)   United States Patent Document. Vol. #4035499,
man LDLo oral 143mg/kg/24H- (143mg/kg) BEHAVIORAL: ANOREXIA (HUMAN

LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL"

LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED"
American Journal of Medicine. Vol. 74, Pg. 349, 1983.
man LDLo oral 714mg/kg (714mg/kg) LIVER: OTHER CHANGES Human Toxicology. Vol. 1, Pg. 25, 1981.
man TDLo oral 9286ug/kg (9.286mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"

SENSE ORGANS AND SPECIAL SENSES: OTHER: EAR
Allergy. Vol. 50(Suppl,
man TDLo oral 714mg/kg (714mg/kg) CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE Postgraduate Medical Journal. Vol. 69, Pg. 52, 1993.
mouse LD50 intraperitoneal 367mg/kg (367mg/kg) BEHAVIORAL: ANALGESIA Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 520, 1965.
mouse LD50 oral 338mg/kg (338mg/kg)   Toxicology and Applied Pharmacology. Vol. 19, Pg. 20, 1971.
mouse LD50 subcutaneous 310mg/kg (310mg/kg)   Human Toxicology. Vol. 3, Pg. 13S, 1984.
pig LDLo intravenous 1gm/kg (1000mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES

LIVER: OTHER CHANGES
Veterinary and Human Toxicology. Vol. 30, Pg. 324, 1988.
rat LD50 intraperitoneal 1205mg/kg (1205mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Studi Sassaresi, Sezione 2. Vol. 57, Pg. 561, 1979.
rat LD50 oral 1944mg/kg (1944mg/kg)   United States Patent Document. Vol. #4636513,
women LDLo oral 260mg/kg (260mg/kg) BEHAVIORAL: COMA

GASTROINTESTINAL: NAUSEA OR VOMITING

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
JAMA, Journal of the American Medical Association. Vol. 236, Pg. 1874, 1976.
women LDLo oral 400mg/kg (400mg/kg) BEHAVIORAL: COMA

LIVER: LIVER FUNCTION TESTS IMPAIRED
Journal of Toxicology, Clinical Toxicology. Vol. 35, Pg. 325, 1997.
women LDLo oral 650mg/kg (650mg/kg)   American Journal of Emergency Medicine. Vol. 6, Pg. 511, 1988.
women LDLo oral 650mg/kg (650mg/kg) VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

VASCULAR: OTHER CHANGES
American Journal of Emergency Medicine. Vol. 6, Pg. 511, 1988.
women TDLo oral 4962ug/kg (4.962mg/kg) LIVER: LIVER FUNCTION TESTS IMPAIRED

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF ENDOCRINE PANCREAS

BLOOD: OTHER CHANGES
Journal of Toxicology, Clinical Toxicology. Vol. 29, Pg. 223, 1991.
women TDLo oral 13mg/kg (13mg/kg) BEHAVIORAL: EXCITEMENT Allergy. Vol. 50(Suppl,
women TDLo oral 325mg/kg (325mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
Postgraduate Medical Journal. Vol. 68, Pg. 116, 1992.
women TDLo oral 490mg/kg (490mg/kg) GASTROINTESTINAL: OTHER CHANGES

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Southern Medical Journal. Vol. 71, Pg. 906, 1978.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 170 deg C   EXP
pKa Dissociation Constant 9.38 (none)   EXP
log P (octanol-water) 0.46 (none)   EXP
Water Solubility 1.40E+04 mg/L 25 EXP
Vapor Pressure 7.00E-06 mm Hg 25 EST
Henry's Law Constant 6.42E-13 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.77E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.