Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Fibrin Tissue Adhesive
RN: 103170-82-7

Note

  • An autologous or commercial tissue adhesive containing FIBRINOGEN and THROMBIN. The commercial product is a two component system from human plasma that contains more than fibrinogen and thrombin. The first component contains highly concentrated fibrinogen, FACTOR VIII, fibronectin, and traces of other plasma proteins. The second component contains thrombin, calcium chloride, and antifibrinolytic agents such as APROTININ. Mixing of the two components promotes BLOOD CLOTTING and the formation and cross-linking of fibrin. The tissue adhesive is used for tissue sealing, HEMOSTASIS, and WOUND HEALING.
 

Classification Codes

  • Coagulants
  • Hematologic Agents
  • Hemostatics
  • Surgical Fixation Devices
  • Tissue Adhesives
* denotes mobile formatted website

Links to Resources

Names and Synonyms

Name of Substance

  • Fibrin Tissue Adhesive

MeSH Heading

  • Fibrin Tissue Adhesive

Synonyms

  • Beriplast
  • Crosseal
  • Fibrin Adhesive
  • Fibrin Glue
  • Fibrin Klebe System Immuno
  • Fibrin Seal
  • Fibrin Sealant
  • Fibrin Sealant System
  • Fibrin Sealant, Human
  • Fibrinogen Adhesive
  • Tisseel
  • Tisseel fibrin sealant
  • Tissel
  • Tissucol
  • Transglutine

Systematic Name

  • Beriplast

Registry Numbers

CAS Registry Number

  • 103170-82-7

System Generated Number

  • 0103170827

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD oral > 100mL/kg (100mL/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 544, 1988.
mouse LD50 intramuscular > 25mL/kg (25mL/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 544, 1988.
mouse LD50 intraperitoneal 30gm/kg (30000mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Oyo Yakuri. Pharmacometrics. Vol. 32, Pg. 801, 1986.
mouse LD50 subcutaneous > 60gm/kg (60000mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Oyo Yakuri. Pharmacometrics. Vol. 32, Pg. 801, 1986.
rat LD50 intramuscular > 20mL/kg (20mL/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 544, 1988.
rat LD50 oral 60gm/kg (60000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 32, Pg. 801, 1986.
rat LD50 subcutaneous 60gm/kg (60000mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Oyo Yakuri. Pharmacometrics. Vol. 32, Pg. 801, 1986.
rat LDLo intraperitoneal 30mL/kg (30mL/kg) GASTROINTESTINAL: OTHER CHANGES

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 544, 1988.