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Substance Name: Pranlukast [INN:BAN]
RN: 103177-37-3
UNII: TB8Z891092
InChIKey: NBQKINXMPLXUET-UHFFFAOYSA-N

Note

  • SRS-A antagonist; leukotriene D4 receptor antagonist.

Molecular Formula

  • C27-H23-N5-O4

Molecular Weight

  • 481.5097
 

Classification Codes

  • Anti-Asthmatic Agents
  • Drug / Therapeutic Agent
  • Hormone Antagonists
  • Hormones, Hormone Substitutes, and Hormone Antagonists
  • Leukotriene Antagonists
  • Reproductive Effect
  • Respiratory System Agents
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Names and Synonyms

Name of Substance

  • Pranlukast [INN:BAN]

Synonyms

  • 4-Oxo-8-(4-(4-phenylbutoxy)benzoylamino)-2-(tetrazol-5-yl)-4H-1-benzopyran
  • Azlaire
  • CCN 00401
  • N-(4-Oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl)-p-(4-phenylbutoxy)benzamide
  • ONO 1078
  • ONO-1078
  • ONO-RS 411
  • Pranlukast
  • RS 411
  • SB 205312
  • UNII-TB8Z891092

Systematic Names

  • Benzamide, N-(4-oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl)-4-(4-phenylbutoxy)-
  • N-(4-Oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl)-p-(4-phenylbutoxy)benzamide

Registry Numbers

CAS Registry Number

  • 103177-37-3

FDA UNII

  • TB8Z891092

System Generated Number

  • 0103177373

Structure Descriptors

InChI

1S/C27H23N5O4/c33-23-17-24(26-29-31-32-30-26)36-25-21(23)10-6-11-22(25)28-27(34)19-12-14-20(15-13-19)35-16-5-4-9-18-7-2-1-3-8-18/h1-3,6-8,10-15,17H,4-5,9,16H2,(H,28,34)(H,29,30,31,32)

InChIKey

NBQKINXMPLXUET-UHFFFAOYSA-N

Smiles

c1ccc(cc1)CCCCOc2ccc(cc2)C(=O)Nc3cccc4c3oc(cc4=O)c5[nH]nnn5

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD oral > 3gm/kg (3000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 44, Pg. 197, 1992.
mouse LD intravenous > 30mg/kg (30mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 44, Pg. 197, 1992.
mouse LD oral > 2gm/kg (2000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 44, Pg. 197, 1992.
mouse LD subcutaneous > 2gm/kg (2000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 44, Pg. 197, 1992.
rat LD intravenous > 30mg/kg (30mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 44, Pg. 197, 1992.
rat LD oral > 2gm/kg (2000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 44, Pg. 197, 1992.
rat LD subcutaneous > 2gm/kg (2000mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER Oyo Yakuri. Pharmacometrics. Vol. 44, Pg. 197, 1992.