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Substance Name: Mitolactol [INN]
RN: 10318-26-0
UNII: LJ2P1SIK8Y
InChIKey: VFKZTMPDYBFSTM-GUCUJZIJSA-N

Note

  • Alkylating antineoplastic toxic to bone marrow; used in breast cancer, also in combination with other drugs.

Molecular Formula

  • C6-H12-Br2-O4

Molecular Weight

  • 307.9648
 

Classification Codes

  • Alkylating Agents
  • Antineoplastic Agents
  • Antineoplastic Agents, Alkylating
  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Noxae
  • Tumor Data
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Names and Synonyms

Name of Substance

  • Mitolactol
  • Mitolactol [INN]

MeSH Heading

  • Mitolactol

Synonyms

  • 1,6-Dibromo-1,6-dideoxy-D-galactitol
  • 1,6-Dibromo-1,6-dideoxydulcitol
  • 1,6-Dibromo-1,6-dideoxydulcitol (VAN)
  • 1,6-Dibromodideoxydulcitol
  • 1,6-Dibromodulcitol
  • AI3-52708
  • CCRIS 6226
  • DBD
  • DBD (alcohol)
  • Dibromdulcit
  • Dibromdulcitol
  • Dibromodulcitol
  • Elobromol
  • Mitolactol
  • Mitolactolum
  • Mitolactolum [INN-Latin]
  • NCI-C04795
  • NSC 104800
  • NSC-104800
  • RTECS MA8540000
  • UNII-LJ2P1SIK8Y

Systematic Names

  • 1,6-Dibromo-1,6-dideoxy-D-galactitol
  • Dibromodulcitol
  • Galactitol, 1,6-dibromo-1,6-dideoxy-

Registry Numbers

CAS Registry Number

  • 10318-26-0

FDA UNII

  • LJ2P1SIK8Y

Other Registry Numbers

  • 14942-40-6
  • 54749-83-6

System Generated Number

  • 0010318260

Structure Descriptors

InChI

1S/C6H12Br2O4/c7-1-3(9)5(11)6(12)4(10)2-8/h3-6,9-12H,1-2H2/t3-,4+,5+,6-

InChIKey

VFKZTMPDYBFSTM-GUCUJZIJSA-N

Smiles

O[C@@H]([C@@H]([C@@H](CBr)O)O)[C@@H](CBr)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human TDLo oral 72mg/kg/D (72mg/kg)   Antibiotics and Chemotherapy Vol. 23, Pg. 50, 1978.
mammal (species unspecified) LD50 oral 700mg/kg (700mg/kg)   Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. Vol. 22(6), Pg. 61, 1976.
mouse LD50 intraperitoneal 550mg/kg (550mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 145, 1967.
mouse LD50 oral 1238mg/kg (1238mg/kg)   National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
rabbit LD50 oral 300mg/kg (300mg/kg)   Cancer Chemotherapy Reports, Part 1. Vol. 56, Pg. 593, 1972.
rat LD50 intraperitoneal 470mg/kg (470mg/kg)   Cancer Chemotherapy Reports, Part 1. Vol. 56, Pg. 593, 1972.
rat LD50 oral 1gm/kg (1000mg/kg)   Cancer Chemotherapy Reports, Part 1. Vol. 56, Pg. 593, 1972.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 187 dec deg C   EXP
log P (octanol-water) -0.29 (none)   EXP
Water Solubility 1.95E+04 mg/L 25 EST
Vapor Pressure 1.54E-08 mm Hg 25 EST
Henry's Law Constant 7.21E-12 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.94E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.