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Substance Name: Devazepide [USAN:INN]
RN: 103420-77-5
UNII: JE6P7QY7NH
InChIKey: NFHRQQKPEBFUJK-HSZRJFAPSA-N

Note

  • A derivative of benzodiazepine that acts on the cholecystokinin A (CCKA) receptor to antagonize CCK-8's (SINCALIDE) physiological and behavioral effects, such as pancreatic stimulation and inhibition of feeding.

Molecular Formula

  • C25-H20-N4-O2

Molecular Weight

  • 408.459
 

Classification Codes

  • Antagonist (Cholecystokinin)
  • Drug / Therapeutic Agent
  • Hormone Antagonists
  • Hormones, Hormone Substitutes, and Hormone Antagonists
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Names and Synonyms

Name of Substance

  • Devazepide
  • Devazepide [USAN:INN]

MeSH Heading

  • Devazepide

Synonyms

  • (S)-N-(2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)indole-2-carboxamide
  • 3(S)-(-)-1,3-Dihydro-3-(2-indolecarbonylamino)-1-methyl-5-phenyl-2H-(1,4)benzodiazepin-2-one
  • BRN 5156082
  • Devazepida
  • Devazepida [INN-Spanish]
  • Devazepide
  • Devazepidum
  • Devazepidum [INN-Latin]
  • L 364,718
  • L 364718
  • L-364,718
  • MK 329
  • MK-329
  • UNII-JE6P7QY7NH

Systematic Name

  • 1H-Indole-2-carboxamide, N-(2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-, (S)-

Registry Numbers

CAS Registry Number

  • 103420-77-5

FDA UNII

  • JE6P7QY7NH

System Generated Number

  • 0103420775

Structure Descriptors

InChI

1S/C25H20N4O2/c1-29-21-14-8-6-12-18(21)22(16-9-3-2-4-10-16)27-23(25(29)31)28-24(30)20-15-17-11-5-7-13-19(17)26-20/h2-15,23,26H,1H3,(H,28,30)/t23-/m1/s1

InChIKey

NFHRQQKPEBFUJK-HSZRJFAPSA-N

Smiles

CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c4ccccc4)c5ccccc15

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
hamster LD50 intraperitoneal 1mg/kg (1mg/kg)   Drugs of the Future. Vol. 14, Pg. 862, 1989.
hamster LD50 oral 1mg/kg (1mg/kg)   Drugs of the Future. Vol. 14, Pg. 862, 1989.
mouse LD50 intraperitoneal 1mg/kg (1mg/kg)   Drugs of the Future. Vol. 14, Pg. 862, 1989.
mouse LD50 oral 1mg/kg (1mg/kg)   Drugs of the Future. Vol. 14, Pg. 862, 1989.