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Substance Name: Amopyroquine hydrochloride
RN: 10350-81-9
UNII: O283Z58SNS
InChIKey: ZIROSOHFLOYBBU-UHFFFAOYSA-N

Classification Codes

  • Chemotherapeutic
  • Drug / Therapeutic Agent

Molecular Formula

  • C20-H20-Cl-N3-O.2Cl-H

Molecular Weight

  • 426.773
 
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Names and Synonyms

Results Name

  • Amopyroquine hydrochloride

Name of Substance

  • Amopyroquin hydrochloride

Synonyms

  • 4-((7-Chloro-4-quinolyl)amino)-alpha-1-pyrrolidinyl-o-cresol dihydrochloride
  • Amopyroquin dihydrochloride
  • Amopyroquin hydrochloride
  • Amopyroquine HCl
  • NSC 157386
  • Propoquin
  • UNII-O283Z58SNS

Systematic Names

  • o-Cresol, 4-((7-chloro-4-quinolyl)amino)-alpha-1-pyrrolidinyl-, dihydrochloride
  • Phenol, 4-((7-chloro-4-quinolinyl)amino)-2-(1-pyrrolidinylmethyl)-, dihydrochloride
  • Phenol, 4-((7-chloro-4-quinolinyl)amino)-2-(1-pyrrolidinylmethyl)-, dihydrochloride (9CI)

Registry Numbers

CAS Registry Number

  • 10350-81-9

FDA UNII

  • O283Z58SNS

Other Registry Number

  • 10449-05-5

Related Registry Number

  • 550-81-2 (Parent)

System Generated Number

  • 0010350819

Molecular Formulas

Molecular Formula

  • C20-H20-Cl-N3-O.2Cl-H

Molecular Formula Fragments

  • C20-H20-Cl-N3-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C20H20ClN3O.2ClH/c21-15-3-5-17-18(7-8-22-19(17)12-15)23-16-4-6-20(25)14(11-16)13-24-9-1-2-10-24;;/h3-8,11-12,25H,1-2,9-10,13H2,(H,22,23);2*1H

InChIKey

ZIROSOHFLOYBBU-UHFFFAOYSA-N

Smiles

c12c(Nc3cc(CN4CCCC4)c(O)cc3)ccnc1cc(Cl)cc2.Cl.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
monkey LDLo intravenous 30mg/kg (30mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) American Journal of Tropical Medicine and Hygiene. Vol. 6, Pg. 987, 1957.
mouse LD50 intravenous 35mg/kg (35mg/kg)   Antibiotics and Chemotherapy Vol. 8, Pg. 450, 1958.
mouse LD50 oral 580mg/kg (580mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Antibiotics and Chemotherapy Vol. 8, Pg. 450, 1958.
rat LD50 intravenous 34mg/kg (34mg/kg)   Antibiotics and Chemotherapy Vol. 8, Pg. 450, 1958.
rat LD50 oral 410mg/kg (410mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Antibiotics and Chemotherapy Vol. 8, Pg. 450, 1958.