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Substance Name: Huperzine B
RN: 103548-82-9
InChIKey: YYWGABLTRMRUIT-HWWQOWPSSA-N

Note

  • Chinese drug isolated from Huperzia serrata; also isolated from Phlegmariurus fordii.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C16-H20-N2-O

Molecular Weight

  • 256.347
 
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Names and Synonyms

Name of Substance

  • Huperzine B

Synonym

  • Huperzine B

Systematic Name

  • Lycodin-1(18H)-one, 8,15-didehydro-

Registry Numbers

CAS Registry Number

  • 103548-82-9

System Generated Number

  • 0103548829

Structure Descriptors

InChI

1S/C16H20N2O/c1-10-7-11-8-14-13(4-5-15(19)18-14)16(9-10)12(11)3-2-6-17-16/h4-5,7,11-12,17H,2-3,6,8-9H2,1H3,(H,18,19)/t11-,12+,16+/m0/s1

InChIKey

YYWGABLTRMRUIT-HWWQOWPSSA-N

Smiles

c1c2c([nH]c(c1)=O)C[C@@H]1C=C(C[C@@]32NCCC[C@@H]13)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 25125ug/kg (25.125mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. Vol. 8, Pg. 117, 1987.
rat LD50 intraperitoneal 43841ug/kg (43.841mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. Vol. 8, Pg. 117, 1987.