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Substance Name: Sumatriptan succinate [USAN]
RN: 103628-48-4
UNII: J8BDZ68989
InChIKey: PORMUFZNYQJOEI-UHFFFAOYSA-N

Note

  • A serotonin agonist that acts selectively at 5HT1 receptors. It is used in the treatment of MIGRAINE DISORDERS.

Molecular Formula

  • C14-H21-N3-O2-S.C4-H6-O4

Molecular Weight

  • 413.4923
 

Classification Codes

  • Antimigraine
  • Drug / Therapeutic Agent
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Sumatriptan succinate [USAN]

Synonyms

  • 1H-Indole-5-methanesulfonamide, 3-(2-(dimethylamino)ethyl)-N-methyl-, butanedioate (1:1)
  • 3-(2-(Dimethylamino)ethyl)-N-methylindole-5-methanesulfonamide succinate (1:1)
  • Alsuma
  • Antibet
  • Arcoiran
  • Diletan
  • GR 43175C
  • Imigran
  • Imijekt
  • Imitrex
  • Imitrex Statdose
  • Micralgin
  • Migmax
  • Migratan
  • Migratriptan
  • Novelian
  • Permicran
  • Sumadol
  • Sumatrin
  • Sumatriptan succinate
  • Sumavel DosePro
  • Sumigrene
  • UNII-J8BDZ68989
  • Zelrix
  • Zembrace SymTouch

Systematic Names

  • 1H-Indole-5-methanesulfonamide, 3-(2-(dimethylamino)ethyl)-N-methyl-, butanedioate (1:1)
  • Butanedioic acid, compd. with 3-(2-(dimethylamino)ethyl)-N-methyl-1H-indole-5-methanesulfonamide (1:1)

Registry Numbers

CAS Registry Number

  • 103628-48-4

FDA UNII

  • J8BDZ68989

Related Registry Number

  • 103628-46-2 (Parent)

System Generated Number

  • 0103628484

Molecular Formulas

Molecular Formula

  • C14-H21-N3-O2-S.C4-H6-O4

Molecular Formula Fragments

  • C14-H21-N3-O2-S
  • C4-H6-O4
  • COMPONENT

Structure Descriptors

InChI

1S/C14H21N3O2S.C4H6O4/c1-15-20(18,19)10-11-4-5-14-13(8-11)12(9-16-14)6-7-17(2)3;5-3(6)1-2-4(7)8/h4-5,8-9,15-16H,6-7,10H2,1-3H3;1-2H2,(H,5,6)(H,7,8)

InChIKey

PORMUFZNYQJOEI-UHFFFAOYSA-N

Smiles

CNS(=O)(=O)Cc1ccc2[nH]cc(CCN(C)C)c2c1.OC(=O)CCC(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD oral > 700mg/kg (700mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 21, Pg. 2065, 1993.
dog LD subcutaneous > 140mg/kg (140mg/kg) BEHAVIORAL: TREMOR

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 21, Pg. 2065, 1993.
rat LD50 intravenous 43112ug/kg (43.112mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

LIVER: OTHER CHANGES
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 21, Pg. 2059, 1993.
rat LD50 oral > 2939mg/kg (2939mg/kg) BEHAVIORAL: TREMOR

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 21, Pg. 2059, 1993.
rat LD50 subcutaneous 1680mg/kg (1680mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 21, Pg. 2059, 1993.