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Substance Name: Pidilizumab [USAN:INN]
RN: 1036730-42-3
UNII: B932PAQ1BQ

Note

  • NCI: A humanized monoclonal antibody directed against human PD-1 (programmed cell death 1; PDCD1), with immunomodulating and antitumor activities. Pidilizumab blocks interaction between the receptor PD-1 with its ligands, PD-1 ligand 1 (PD-1L1) and PD-1 ligand 2 (PD-1L2), resulting in the attenuation of apoptotic processes in lymphocytes, primarily effector/memory T cells, and the augmentation of the anti-tumor activities of NK cells. PD-1 is an inhibitory receptor belonging to the B7-receptor family that is expressed on lymphocytes and myeloid cells; its ligands, PD-1L1 and PD-1L2, are expressed not only by hematopoietic cells but also by cells in non-lymphoid tissues. (NCI Thesaurus)

Molecular Formula

  • C6424-H9920-N1704-O2002-S48
 

Classification Code

  • Treatment of Cancer and Infectious Diseases
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Links to Resources

Names and Synonyms

Name of Substance

  • Pidilizumab [USAN:INN]

Synonyms

  • CT 011
  • CT-011
  • Immunoglobulin G1, anti-(receptor PD-1 (Programmed Death 1) (human-mouse monoclonal CT-011 gamma1-chain), disulfide with human-mouse monoclonal CT-011 kappa-chain, dimer
  • Pidilizumab
  • UNII-B932PAQ1BQ

Systematic Name

  • Immunoglobulin G1, anti-(human programmed cell death 1); humanized mouse monoclonal CT-011 gamma1 heavy chain (220-213')-disulfide with humanized mouse monoclonal CT-011 kappa light chain dimer (226-226'':229-229'')-bisdisulfide, glycosylated (CT-011 is expressed in NSO cells)

Registry Numbers

CAS Registry Number

  • 1036730-42-3

FDA UNII

  • B932PAQ1BQ

System Generated Number

  • 1036730423