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Substance Name: Fasudil [INN]
RN: 103745-39-7
UNII: Q0CH43PGXS
InChIKey: NGOGFTYYXHNFQH-UHFFFAOYSA-N

Note

  • Intracellular calcium antagonist.

Molecular Formula

  • C14-H17-N3-O2-S

Molecular Weight

  • 291.3733
 

Classification Codes

  • Calcium Channel Blockers
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Membrane Transport Modulators
  • Protein Kinase Inhibitors
  • Vasodilator Agents
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Names and Synonyms

Name of Substance

  • Fasudil
  • Fasudil [INN]

Synonyms

  • 1-(5-Isoquinolinesulfonyl)homopiperazine
  • AT 877
  • AT-877
  • Fasudil
  • Fasudilum
  • Fasudilum [INN-Latin]
  • HA 1077
  • HA1077
  • Hexahydro-1-(5-isoquinolinylsulfonyl)-1H-1,4-diazepine
  • UNII-Q0CH43PGXS

Systematic Names

  • 1H-1,4-Diazepine, hexahydro-1-(5-isoquinolinylsulfonyl)-
  • Hexahydro-1-(5-isoquinolylsulfonyl)-1H-1,4-diazepine

Registry Numbers

CAS Registry Number

  • 103745-39-7

FDA UNII

  • Q0CH43PGXS

System Generated Number

  • 0103745397

Structure Descriptors

InChI

1S/C14H17N3O2S/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14/h1,3-5,7,11,15H,2,6,8-10H2

InChIKey

NGOGFTYYXHNFQH-UHFFFAOYSA-N

Smiles

O=S(=O)(N1CCCNCC1)c2cccc3cnccc23

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 unreported 73500ug/kg (73.5mg/kg)   United States Patent Document. Vol. #4678783,