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Substance Name: Gimeracil [INN]
RN: 103766-25-2
UNII: UA8SE1325T
InChIKey: ZPLQIPFOCGIIHV-UHFFFAOYSA-N

Note

  • A biochemical and pharmacological modulator of 5-FU.

    NCI: A pyridine derivative with antitumor activity. Gimeracil enhances the antitumor activity of fluoropyrimidines by competitively and reversibly inhibiting the enzyme dihydropyrimidine dehydrogenase causing decreased degradation of the fluoropyrimidines. (NCI Thesaurus)

Molecular Formula

  • C5-H4-Cl-N-O2

Molecular Weight

  • 145.545
 
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Names and Synonyms

Name of Substance

  • Gimeracil
  • Gimeracil [INN]

Synonyms

  • 5-Chloro-2,4-dihydroxypyridine
  • 5-Chloro-2,4-pyridinediol
  • 5-Chloro-4-hydroxy-2(1H)-pyridinone
  • Cdhp compound
  • Gimeracil
  • Gimestat
  • UNII-UA8SE1325T

Systematic Name

  • 2(1H)-Pyridinone, 5-chloro-4-hydroxy-

Registry Numbers

CAS Registry Number

  • 103766-25-2

FDA UNII

  • UA8SE1325T

System Generated Number

  • 0103766252

Structure Descriptors

InChI

1S/C5H4ClNO2/c6-3-2-7-5(9)1-4(3)8/h1-2H,(H2,7,8,9)

InChIKey

ZPLQIPFOCGIIHV-UHFFFAOYSA-N

Smiles

c1c(c(cc([nH]1)=O)O)Cl