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Substance Name: Miboplatin [INN]
RN: 103775-75-3
UNII: 06241B5S4P
InChIKey: XXUHLUDUCZQMDI-UTYJZAQGSA-L

Classification Codes

  • Antineoplastic Agents
  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C11-H18-N2-O4-Pt

Molecular Weight

  • 437.3532
 
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Names and Synonyms

Name of Substance

  • DWA 2114
  • Miboplatin
  • Miboplatin [INN]

Synonyms

  • (-)-(R)-2-Aminomethylpyrrolidine(1,1-cyclobutanedicarboxylato)platinum(II) hydrate
  • (-)-Cis-((R)-2-(aminomethyl)pyrrolidine)(1,1-cyclobutanedicarboxylato)platinum
  • CCRIS 5235
  • DWA 2114R
  • Miboplatin
  • Platinum, (1,1-cyclobutanedi(carboxylato-kappaO)(2-))(2-pyrrolidinemethanamine-kappaN1,kappaN2)-, (SP-4-3(1R-(cis))-
  • Platinum, (1,1-cyclobutanedicarboxylato(2-))(2-pyrrolidinemethanamine-Nalpha,N1)-, (SP-4-3-(1R-cis))-
  • UNII-06241B5S4P

Systematic Names

  • (-)-Cis-((R)-2-(aminomethyl)pyrrolidine)(1,1-cyclobutanedicarboxylato)platinum
  • Dwa2114R
  • Platinum, (1,1-cyclobutanedi(carboxylato-kappaO)(2-))((1R,2R)-2-pyrrolidinemethanamine-kappaN1,kappaN2)-, (SP-4-3)-
  • Platinum, (1,1-cyclobutanedicarboxylato(2-))(2-pyrrolidinemethanamine-N(sup alpha),N(sup 1))-,(SP-4-3-(1R-cis))-, monohydrate
  • Platinum, (1,1-cyclobutanedicarboxylato(2-))(2-pyrrolidinemethanamine-Nalpha,N1)-, (SP-4-3-(R))-

Registry Numbers

CAS Registry Number

  • 103775-75-3

FDA UNII

  • 06241B5S4P

System Generated Number

  • 0103775753

Structure Descriptors

InChI

1S/C6H8O4.C5H12N2.Pt/c7-4(8)6(5(9)10)2-1-3-6;6-4-5-2-1-3-7-5;/h1-3H2,(H,7,8)(H,9,10);5,7H,1-4,6H2;/q;;+2/p-2/t;5-;/m.1./s1

InChIKey

XXUHLUDUCZQMDI-UTYJZAQGSA-L

Smiles

[Pt+2].NC[C@H]1CCCN1.[O-]C(=O)C2(CCC2)C(=O)[O-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 40mg/kg (40mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl,
mouse LD50 intravenous 150mg/kg (150mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BLOOD: CHANGES IN SPLEEN

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl,
rat LD50 intravenous 107mg/kg (107mg/kg) BLOOD: CHANGES IN SPLEEN

GASTROINTESTINAL: OTHER CHANGES

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl,