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Substance Name: Niraparib [USAN:INN]
RN: 1038915-60-4
UNII: HMC2H89N35
InChIKey: PCHKPVIQAHNQLW-CQSZACIVSA-N

Note

  • NCI: An inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. PARP Inhibitor MK4827 inhibits PARP activity, enhancing the accumulation of DNA strand breaks and promoting genomic instability and apoptosis. The PARP family of proteins detect and repair single strand DNA breaks by the base-excision repair (BER) pathway. The specific PARP family member target for PARP inhibitor MK4827 is unknown. (NCI Thesaurus)

Molecular Formula

  • C19-H20-N4-O

Molecular Weight

  • 320.394
 

Classification Codes

  • Antineoplastic
  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Poly(ADP-ribose) Polymerase Inhibitors
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Names and Synonyms

Results Name

  • Niraparib [USAN:INN]

Name of Substance

  • 2-(4-(Piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide
  • Niraparib [USAN:INN]

Synonyms

  • MK 4827 (Base)
  • Niraparib
  • UNII-HMC2H89N35
  • ZEJULA

Registry Numbers

CAS Registry Number

  • 1038915-60-4

FDA UNII

  • HMC2H89N35

System Generated Number

  • 1038915604

Structure Descriptors

InChI

1S/C19H20N4O/c20-19(24)17-5-1-3-15-12-23(22-18(15)17)16-8-6-13(7-9-16)14-4-2-10-21-11-14/h1,3,5-9,12,14,21H,2,4,10-11H2,(H2,20,24)/t14-/m1/s1

InChIKey

PCHKPVIQAHNQLW-CQSZACIVSA-N

Smiles

c1(cccc2c1nn(c2)c1ccc(cc1)[C@H]1CNCCC1)C(=O)N