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Substance Name: Niraparib hydrochloride
RN: 1038915-64-8
UNII: L4JFC1PHCI
InChIKey: YXYDNYFWAFBCAN-PFEQFJNWSA-N

Note

  • NCI: An inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. PARP Inhibitor MK4827 inhibits PARP activity, enhancing the accumulation of DNA strand breaks and promoting genomic instability and apoptosis. The PARP family of proteins detect and repair single strand DNA breaks by the base-excision repair (BER) pathway. The specific PARP family member target for PARP inhibitor MK4827 is unknown. (NCI Thesaurus)

Molecular Formula

  • C19-H20-N4-O.Cl-H

Molecular Weight

  • 356.8549
 

Classification Codes

  • Antineoplastic agents
  • Enzyme Inhibitors
  • Poly(ADP-ribose) Polymerase Inhibitors
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Names and Synonyms

Results Name

  • Niraparib hydrochloride

Name of Substance

  • 2-(4-(Piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide hydrochloride
  • Niraparib hydrochloride

Synonyms

  • 2-(4-((3S)-Piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide hydrochloride
  • MK 4827
  • MK-4827
  • MK4827
  • Niraparib HCl
  • UNII-L4JFC1PHCI

Systematic Name

  • 2H-Indazole-7-carboxamide, 2-(4-(3S)-3-piperidinylphenyl)-, hydrochloride (1:1)

Registry Numbers

CAS Registry Number

  • 1038915-64-8

FDA UNII

  • L4JFC1PHCI

System Generated Number

  • 1038915648

Molecular Formulas

Molecular Formula

  • C19-H20-N4-O.Cl-H

Molecular Formula Fragments

  • C19-H20-N4-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C19H20N4O.ClH/c20-19(24)17-5-1-3-15-12-23(22-18(15)17)16-8-6-13(7-9-16)14-4-2-10-21-11-14;/h1,3,5-9,12,14,21H,2,4,10-11H2,(H2,20,24);1H/t14-;/m1./s1

InChIKey

YXYDNYFWAFBCAN-PFEQFJNWSA-N

Smiles

c1(cccc2c1nn(c2)c1ccc(cc1)[C@H]1CNCCC1)C(=O)N.Cl