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Substance Name: Maxacalcitol [USAN:INN]
RN: 103909-75-7
UNII: N2UJM5NBF6
InChIKey: DTXXSJZBSTYZKE-ZDQKKZTESA-N

Classification Codes

  • Anticarcinogenic Agents
  • Antineoplastic Agents
  • Antipsoriatic (Vitamin D Analogue which Inhibits Proliferation of Cultured Keratinocytes and Induces Terminal Differentiation)
  • Dermatologic Agents
  • Drug / Therapeutic Agent
  • Protective Agents
  • Reproductive Effect

Molecular Formula

  • C26-H42-O4

Molecular Weight

  • 418.6138
 
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Names and Synonyms

Name of Substance

  • Maxacalcitol
  • Maxacalcitol [USAN:INN]

Synonyms

  • (+)-(5Z,7E,20S)-20-(3-Hydroxy-3-methylbutoxy)-9,10-secopregna-5,7,10(19)-triene-1alpha,3beta-diol
  • (1S-(1alpha(R*),3abeta,4E(1S*,3R*,5Z),7aalpha))-4-Methylene-5-(2-(octahydro-1-(1-(3-hydroxy-3-methylbutoxy)ethyl)-7a-methyl-4H-inden-4-ylidiene)ethylidene-1,3-cyclohexanediol
  • 1alpha,25-Dihydroxy-22-oxavitamin D3
  • 22-Oxa-1,25-dihydroxyvitamin D3
  • 22-Oxa-calcitriol
  • 22-Oxacalcitriol
  • Maxacalcitol
  • Maxacalcitriol
  • MC 1275
  • OCT
  • Prezios
  • Sch 209579
  • UNII-N2UJM5NBF6

Systematic Names

  • 1,3-Cyclohexanediol, 4-methylene-5-((2E)-((1S,3aS,7aS)-octahydro-1-((1S)-1-(3-hydroxy-3-methylbutoxy)ethyl)-7a-methyl-4H-inden-4-ylidene)ethylidene)-, (1R,3S,5Z)-
  • 1,3-Cyclohexanediol, 4-methylene-5-(2-(octahydro-1-(1-(3-hydroxy-3-methylbutoxy)ethyl)-7a-methyl-4H-inden-4-ylidene)ethylidene)-, (1S-(1alpha(R*),3abeta,4E(1S*,3R*,5Z),7aalpha))-

Registry Numbers

CAS Registry Number

  • 103909-75-7

FDA UNII

  • N2UJM5NBF6

System Generated Number

  • 0103909757

Structure Descriptors

InChI

1S/C26H42O4/c1-17-20(15-21(27)16-24(17)28)9-8-19-7-6-12-26(5)22(10-11-23(19)26)18(2)30-14-13-25(3,4)29/h8-9,18,21-24,27-29H,1,6-7,10-16H2,2-5H3/b19-8+,20-9-/t18-,21+,22+,23-,24-,26+/m0/s1

InChIKey

DTXXSJZBSTYZKE-ZDQKKZTESA-N

Smiles

C[C@@H]([C@H]1CC[C@@H]\2[C@@]1(CCC/C2=C\C=C/3\C[C@H](C[C@@H](C3=C)O)O)C)OCCC(C)(C)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 800ug/kg (0.8mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

GASTROINTESTINAL: NAUSEA OR VOMITING

BLOOD: CHANGES IN LEUCOCYTE (WBC) COUNT
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 26(Suppl,
rat LD50 intravenous 8mg/kg (8mg/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

CARDIAC: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 26(Suppl,